Graves Disease Graves disease is an autoimmune thyroid disease caused by thyrotroping-stimulating immunoglobulins (TSIs) which stimulate TSH receptors resulting in elevated basal thyroid activity. Unlike toxic adenoma, 50% of patients with Grave’s disease undergo remission within the first year of…
Insulin Insulin formulations Formulation Examples Nota bene Rapid-acting Lispro, aspart, glulisine Typically given before meals Short-acting Regular insulin, NPH/regular preparations (75/25, 70/30, 50/50) Intermediate-acting Non-proteated Hagedorn (NPH) First-line insulin. May be prescribed along-side soluble insulin seperately or as pre-mixed solution.…
Oral Glucose Lowering Agents (OGLAs) Class Example Biguanides Metofrmin SGLT-2 inhibitors Canagliflozin, empagliflozin, dapagliflozin GLP-1 agonists Exenatide, liraglutide, semaglutide DPP-4 inhibitors Sitagliptin, linagliptin Sulfonylureas Glipizide, gliburide, chlorpropamide Thiazolidinediones Pioglitazone, rosiglitazone Prescribing OGLAs Metformin Metformin is a biguanide. It is one…
Assessment of a patient with newly diagnosed diabetes Look for evidence of: Routine Review of a known DM patient
Hypothyroidism Hypothyroidism is a deficiency of the thyroid hormones T3 and T4. The presentation of thyroid disease can be subtle and non-specific since almost all cell nuclei have thyroid receptors which affect various metabolic processes. Prognosis is good if treated…
Osteoporosis Osteoporosis is a skeletal disease characterised by low bone mineral density and microarchitectural defects. This leads to increased fragility and susceptibility to fracture. It is commonly asymptomatic until fractures happen. It is diagnosed objectively using a DEXA Scan with…
Rheumatic Heart Disease (RHD) Rheumatic heart disease (RHD) is a chronic, systemic, immune-mediated condition that develops as a serious complication of rheumatic fever (RF), often following recurrent episodes of acute illness. It is the most significant consequence of acute rheumatic…
Overview Frykman classification of distal radius fracture (based on joint involvement +/- ulnar styloid fracture) Classification Description Type I Transverse extra-articular fracture of the distal radial metaphysis Type II Type I + ulnar styloid Type III Fracture extends into radiocarpal…
Paediatric Ankle Fracture Ankle fractures are common in children and range from very simple to complex Salter-Harris type Treatment Type I and II Closed reduction and casting Type III and IV Closed reduction and external fixation
Paediatric Femoral Shaft Fracture Femoral shaft fractures are the most common fracture-related indication for admission in paediatrics. However, they only account for about 2% of paediatric fractures. Femoral shaft fractures should prompt concern for non-accidental injury in patients < 3…