Acute Tonsillitis

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Last updated: May 7, 2026Bookmark

Acute tonsillitis is an acute inflammation of the palatine tonsils. It is commonly caused by viruses.

It peaks between 6 and 15 years of age.

Classification of tonsillitis

ClassificationDescription
Acute catarrhal tonsillitis (superficial)The tonsillitis is part of a generalized pharyngitis. It is commonly viral in origin.
Acute follicular tonsillitisThe infection spreads into the crypts, which get filled with pus. It appears as yellowish spots.
Acute parenchymatous tonsillitisThe infection spreads to the parenchyma. The tonsils appear enlarged and red.
Acute membranous tonsillitisExudates from the crypts coalesce and form a membrane over the tonsils

Grading of Tonsillar enlargement

GradeDefinitionDescription
1< 25%Tonsils fill less than 25% of the transverse oropharyngeal space measured
225-49%Tonsils fill less than 50% of the transverse oropharyngeal space
350-74%Tonsils fill less than 75% of the transverse oropharyngeal space
4> 75%Tonsils fill 75% or more of the oropharyngeal space
  • Causative organisms
    • Viruses
      • Herpes simplex virus
      • Epstein-Barr virus
      • Cytomegalovirus
      • Adenovirus
      • Measles virus
    • Bacteria
      • Streptococcus pyogenes
      • Haemophilus influenzae
      • Streptococcus pneumoniae
      • Staphylococcus aureus
  • Risk factors
    • Children and adolescents
    • Close contact with infected individuals
    • Crowded environments such as schools and day-care centres
    • Poor hygiene
    • Immunodeficiency
    • Allergies
    • Tobacco smoke exposure
    • Gastroesophageal reflux disease
  • Signs and symptoms
    • Throat pain (sore throat)
    • Foul breath
    • Difficulty swallowing (dysphagia)
    • Pain on swallowing (odynophagia)
    • Fever
      • May be associated with chills and rigors
    • Ear pain
    • Airway obstruction
      • Mouth breathing
      • Snoring
      • Sleep-disordered breathing (sleep apnea)
    • Headache, malaise
    • Constipation
    • Abdominal pain due to mesenteric lymphadenitis
  • Physical examination
    • Fetid breath
    • Open mouth breathing
    • Subtle voice change (Thicker voice)
    • Hyperemia of the pillars, soft palate, and uvula
    • Tonsils are red and swollen
    • Yellowish spots of pus (acute follicular tonsillitis)
    • Whitish membrane over the medial surface of the tonsils (acute membranous tonsilitis; can be wiped with a swab)
    • Tonsils are enlarged and almost meet in the midline
    • Odema of the uvula and soft palate (acute parenchymatous tonsillitis)
    • Jugulodigastric lymphadenitis
    • Stiff neck
  • Differentials
    • Peritonsillar abscess
    • Infectious mononucleosis
    • Viral pharyngitis
    • Membranous tonsillitis
    • Diphtheria
    • Vincent angina
    • Candidiasis of the tonsils
    • Infectious mononucleosis
    • Agranulocytosis
    • Leukemia
    • Aphthous ulcers
    • Malignant tonsil
    • Traumatic ulcer
  • Investigations
    • Complete blood count
    • Peripheral blood film
    • Throat swab and culture
    • Rapid antigen detection test
    • Serum testing for anti-streptococcal antibodies
  • Treatment
    • Reassurance
      • Symptoms usually last for around 1 week
    • Bed rest
    • Plenty of fluids
    • Analgesia and antipyretics
    • Antibiotics (phenoxymethylpenicillin or erythromycin)
    • Antihistamines and decongestants
    • Antiseptic gargle
    • For airway obstruction
      • Nasal airway device
      • Intravenous corticosteroids
      • Humidified oxygen
    • Tonsillectomy is the definitive treatment
  • Complications
Reference Intervals ›
Biochemistry
ACTHP: <80 ng/L
ALTP: 5–35 U/L
AlbuminP: 35–50 g/L
AldosteroneP: 100–500 pmol/L
Alk. phosphataseP: 30–130 U/L
α-AmylaseP: 0–180 IU/dL
α-FetoproteinS: <10 kU/L
Angiotensin IIP: 5–35 pmol/L
ADHP: 0.9–4.6 pmol/L
ASTP: 5–35 U/L
BicarbonateP: 24–30 mmol/L
BilirubinP: 3–17 μmol/L
BNPP: <50 ng/L
CRPP: <10 mg/L
CalcitoninP: <0.1 mcg/L
Calcium (ionized)P: 1.0–1.25 mmol/L
Calcium (total)P: 2.12–2.60 mmol/L
ChlorideP: 95–105 mmol/L
CholesterolP: <5.0 mmol/L
VLDLP: 0.128–0.645 mmol/L
LDLP: <2.0 mmol/L
HDLP: 0.9–1.93 mmol/L
Cortisol AMP: 450–700 nmol/L
Cortisol MidnightP: 80–280 nmol/L
CK ♂P: 25–195 U/L
CK ♀P: 25–170 U/L
CreatinineP: 70–100 μmol/L
FerritinP: 12–200 mcg/L
FolateS: 2.1 mcg/L
FSHP: 2–8 U/L ♂; >25 menopause
GGT ♂P: 11–51 U/L
GGT ♀P: 7–33 U/L
Glucose (fasting)P: 3.5–5.5 mmol/L
Growth hormoneP: <20 mu/L
HbA1C (DCCT)B: 4–6%
HbA1C (IFCC)B: 20–42 mmol/mol
Iron ♂S: 14–31 μmol/L
Iron ♀S: 11–30 μmol/L
Lactate (venous)P: 0.6–2.4 mmol/L
Lactate (arterial)P: 0.6–1.8 mmol/L
LDHP: 70–250 U/L
LHP: 3–16 U/L
MagnesiumP: 0.75–1.05 mmol/L
OsmolalityP: 278–305 mosmol/kg
PTHP: 0.8–8.5 pmol/L
PotassiumP: 3.5–5.3 mmol/L
Prolactin ♂P: <450 U/L
Prolactin ♀P: <600 U/L
PSAP: 0–4 mcg/mL
Protein (total)P: 60–80 g/L
Red cell folateB: 0.36–1.44 μmol/L
Renin (erect)P: 2.8–4.5 pmol/mL/h
Renin (recumbent)P: 1.1–2.7 pmol/mL/h
SodiumP: 135–145 mmol/L
TBGP: 7–17 mg/L
TSHP: 0.5–4.2 mU/L
T4P: 70–140 nmol/L
Free T4P: 9–22 pmol/L
TIBCS: 54–75 μmol/L
TriglyceridesP: 0.50–2.3 mmol/L
T3P: 1.2–3.0 nmol/L
Troponin TP: <0.1 mcg/L
Urate ♂P: 210–480 μmol/L
Urate ♀P: 150–390 μmol/L
UreaP: 2.5–6.7 mmol/L
Vitamin B12S: 0.13–0.68 nmol/L
Vitamin DS: 50 nmol/L
Arterial Blood Gases
pH7.35–7.45
PaCO₂4.7–6.0 kPa
PaO₂>10.6 kPa
Base excess±2 mmol/L
Urine
Cortisol (free)<280 nmol/24h
Hydroxyindole acetic acid16–73 μmol/24h
Hydroxymethylmandelic acid16–48 μmol/24h
Metanephrines0.03–0.69 μmol/mmol cr.
Osmolality350–1000 mosmol/kg
17-Oxogenic steroids ♂28–30 μmol/24h
17-Oxogenic steroids ♀21–66 μmol/24h
17-Oxosteroids ♂17–76 μmol/24h
17-Oxosteroids ♀14–59 μmol/24h
Phosphate (inorganic)15–50 mmol/24h
Potassium14–120 mmol/24h
Protein<150 mg/24h
Protein/creatinine ratio<3 mg/mmol
Sodium100–250 mmol/24h
Haematology
WCC4.0–11.0 ×10⁹/L
RBC ♂4.5–6.5 ×10¹²/L
RBC ♀3.9–5.6 ×10¹²/L
Hb ♂130–180 g/L
Hb ♀115–160 g/L
PCV ♂0.4–0.54 L/L
PCV ♀0.37–0.47 L/L
MCV76–96 fL
MCH27–32 pg
MCHC300–360 g/L
RDW11.6–14.6%
Neutrophils2.0–7.5 ×10⁹/L (40–75%)
Lymphocytes1.0–4.5 ×10⁹/L (20–45%)
Eosinophils0.04–0.44 ×10⁹/L (1–6%)
Basophils0–0.10 ×10⁹/L (0–1%)
Monocytes0.2–0.8 ×10⁹/L (2–10%)
Platelets150–400 ×10⁹/L
Reticulocytes0.8–2.0% / 25–100 ×10⁹/L
Prothrombin time10–14 s
APTT35–45 s
Paediatric
Pulse Rate (bpm)
Neonate140–160
Infant <1yr120–140
1–5 years110–130
5–12 years80–120
>12 years70–100
Respiratory Rate (tachypnoea)
0–2 months≥60/min
2–12 months≥50/min
1–5 years≥40/min
>5 years≥30/min
Blood Pressure (mmHg)
Term65/45
1 year75/50
4 years85/60
8 years95/65
10 years100/70
Weight Formulas
3–12 months(a + 9)/2 kg
1–6 years2a + 8 kg
>6 years(7a − 5)/2 kg
Haemoglobin (g/dL)
Term newborn13–20
1 month11–18
2 months10–15
1–2 years10–13
>2 years11–14
MUAC (6 months–5 years)
Obese>17.5 cm
Normal13.5–17.4 cm
At risk12.5–13.4 cm
Moderate malnutrition11.5–12.4 cm
Severe malnutrition<11.5 cm
Developmental Milestones
Social smile1.5 months
Head control4 months
Sits unsupported7 months
Crawls10 months
Stands unsupported10–12 months
Walks12–13 months
Talks18 months
CSF WBC (/mm³)
Term newborn0–25
>2 weeks0–5
Calculator ›

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