Table Of Contents
Psychostimulants
Psychostimulants increase the availability of DA and NE in the synaptic cleft (by increasing release and blocking reuptake). Stimulants should not be used to treat mood disorders, even as adjuncts. It is better to use activating antidepressants (such as bupropion and venlafaxine)
Dextroamphetamine, Methylphenydate
Selected psychostimulants
| Psychostimulant | Nota bene |
|---|---|
| Dextroapmhetamine (Adderall) | d-isomer of amphetamine. It has a high potential for abuse/diversion. Decreases seizure threshold. Watch for weight loss, insomnia, and exacerbation of tics. |
| Methylphenidate (Concerta) | Similar to amphetamine. Watch for leukopenia or anemia |
| Atomoxetine (Strattera) | Inhibits presynaptic norepinephrine reuptake. Less appetite suppression and insomnia. Less abuse potential |
| Modafinil (Provigil) | Useful in narcolepsy |
- Indications for stimulants
- ADHD
- Narcolepsy
- Excessive daytime sleepiness due to sleep apnea
- Adverse effects
- Restlessness
- Insomnia
- Poor appetite
- Dizziness
- Tremor
- Palpitations
- Arrhythmia
Stimulants used for Mood Disorders
Modafinil (Provigil) is a stimulant that is often used clinically in mood disorders.
