Hypothermia and Shivering

Hypothermia Hypothermia is defined as a core body temperature less than 36 degrees Celsius. Core body temperature can be measured in the nasopharynx, distal eosophagus, tympanic membrane and pulmonary artery. Skin is generally much cooler than core temperature. Mechanisms to…

Post-operative Nausea and Vomiting (PONV)

Overview Post-operative Nausea and Vomiting is the leading cause of delayed discharge from PACU. Current recommendations is at least 2 prophylactic drugs for patients with at least 1 risk factor for PONV. Combinations should be with drugs that have different…

Intra-op Hypotension and Hypertension

Overview Blood pressure represents the force exerted by the circulating blood on the walls of blood vessels. It is determined by cardiac output (CO) and systemic vascular resistance (SVR). (MAP – SVR) = HR X SVR CO = HR X…

Transfusion Therapy

Pre-Transfusion Testing Group and Screen (Type and Screen) Antigens that are not present in screened cells are unlikely to cause significant hemolytic reactions (0.2% risk of transfusion reaction if only type and screen is done). They can be safely transfused…

IV Fluids and Resuscitation

Overview Definition of terms Term Definition Osmosis Spontaneous movement of water across a semi-permeable membrane from a region of low solute concentration to one of high solute concentration which tends to equalize the solute concentration on either side of the…

Shock

Overview Shock is defined as a state of global cellular and tissue hypoxia due to either reduced oxygen delivery, increased oxygen consumption, inadequate oxygen utilization, or a combination of these processes. Shock is almost always caused by low blood pressure…

Neuromuscular Blocking Agents (NMBAs)

Overview NMBAs facilitate intubation, mechanical ventilation, and surgical relaxation. Categories of NMBAs Category Examples Depolarizing Succinylcholine Non-depolarizing Atracurium, Cisatracurium, Rocuronium, Vecuronium Agent ED 95 (mg/kg) Intubating Dose (mg/kg) Onset (min Duration to 25% recovery (min) Intra-op maintenance Metabolism and Excretion…

Local Anaesthetic Agents

Local Anaesthetics Local anesthetics provide analgesia and anaesthesia by disrupting the conduction of impulses along nerve fibers. They block voltage-gated Na+, thus inhibiting the influx of sodium and preventing an action potential from being reached. They are weak bases in…