Thoracocentesis (Pleurocentesis)

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Last updated: October 5, 2026Bookmark

Thoracocentesis is the insertion of a needle or catheter into the pleural space to remove fluid or air.

Classification

ClassificationDescription
Diagnostic thoracocentesisPerformed to determine the cause of pleural effusion and exclude infection
Therapeutic thoracocentesisPerformed to relieve symptomatic effusions

Common causes of pleural effusion

CategoryCauses
TransudativeHeart failure, cirrhosis (hepatic hydrothorax), and nephrotic syndrome
ExudativeInfection (parapneumonic effusion), malignancy, TB, pulmonary embolism, autoimmune disease, and chylothorax

Stages of a parapneumonic effusion

StageFeatures
Simple/exudative stageFree-flowing. Consider drainage when thickness is >10 mm
Complicated or fibropurulent stagepH < 7.20, glucose < 3.3 mmol/L, ↑ LDH, may be loculated, cultures can be negative, and antibiotics alone are insufficient and drainage required
EmpyemaPus in pleural space OR Positive Gram stain/culture
  • Indications
    • Diagnostic thoracocentesis (20 – 30 mL for analysis)
      • Unexplained pleural effusion
      • Suspected pleural infection or empyema or TB
      • Suspected malignancy
      • Differentiating cardiac from non-cardiac causes
    • Therapeutic thoracocentesis (1 – 1.5 L per session)
      • Large symptomatic effusion causing dyspnoea or lung compression
      • Empyema
      • Hemothorax
      • Before pleurodesis
      • Drain placement when rapid reaccumulation is expected
  • Contraindications
  • Procedure
    • Review Chest X-ray, CT scan or Ultrasound
    • Informed consent
    • Positioning
      • Sitting and leaning forward with the arms supported by pillows or overbed table
    • Site
      • Posterior mid-scapular line at the 6th – 8th intercostal space, depending on fluid location
      • Ultrasound can be used to identify the safest pocket and reduce complications
    • Sterile preparation with chlorhexidine/povidone iodine and draping
    • Local anaesthesia up to the pleura with 1% plain lidocaine
    • Insert the needle just above the superior border of the rib to avoid the neurovascular bundle
    • Aspirate while advancing
    • Advance catheter once pleural fluid is obtained
    • Drain slowly
    • Remove the catheter and apply pressure
    • Send fluid for analysis if diagnostic evaluation is required
  • Pleural fluid analysis
    • Protein
    • LDH
    • pH
      • pH < 7.2 in parapnemonic effusions
    • Glucose
      • < 3.3 mmol/L in parapneumonic effusion, empyema, malignancy, rheumatoid pleuritis or TB
    • Cell count/differential
      • Neutrophil predominant in parapneumonic effusion or early PE
      • Lymphocyte predominant in TB, malignancy, chronic effusion, or lymphoma
      • Eosinophils in parasitic disease, drugs, or blood in pleural space
    • Gram stain and culture
    • Cytology
    • TB testing (AFB, GeneXpert, culture or ADA)
  • Light’s criteria
    • A pleural fluid is an exudate if any one of the following is present:
      • Pleural protein/serum protein >0.5
      • Pleural LDH/serum LDH > 0.6
        • Pleural LDH > 2/3 upper limit of normal serum LDH
  • Complications
    • Pneumothorax (most common)
    • Vascular injury → bleeding → haemothorax
    • Pain
    • Infection
    • Intercostal nerve injury
    • Liver or spleen puncture if inserted to low
    • Re-expansion pulmonary oedema
    • Vasovagal symptoms
Reference Intervals ›
Biochemistry
ACTHP: <80 ng/L
ALTP: 5–35 U/L
AlbuminP: 35–50 g/L
AldosteroneP: 100–500 pmol/L
Alk. phosphataseP: 30–130 U/L
α-AmylaseP: 0–180 IU/dL
α-FetoproteinS: <10 kU/L
Angiotensin IIP: 5–35 pmol/L
ADHP: 0.9–4.6 pmol/L
ASTP: 5–35 U/L
BicarbonateP: 24–30 mmol/L
BilirubinP: 3–17 μmol/L
BNPP: <50 ng/L
CRPP: <10 mg/L
CalcitoninP: <0.1 mcg/L
Calcium (ionized)P: 1.0–1.25 mmol/L
Calcium (total)P: 2.12–2.60 mmol/L
ChlorideP: 95–105 mmol/L
CholesterolP: <5.0 mmol/L
VLDLP: 0.128–0.645 mmol/L
LDLP: <2.0 mmol/L
HDLP: 0.9–1.93 mmol/L
Cortisol AMP: 450–700 nmol/L
Cortisol MidnightP: 80–280 nmol/L
CK ♂P: 25–195 U/L
CK ♀P: 25–170 U/L
CreatinineP: 70–100 μmol/L
FerritinP: 12–200 mcg/L
FolateS: 2.1 mcg/L
FSHP: 2–8 U/L ♂; >25 menopause
GGT ♂P: 11–51 U/L
GGT ♀P: 7–33 U/L
Glucose (fasting)P: 3.5–5.5 mmol/L
Growth hormoneP: <20 mu/L
HbA1C (DCCT)B: 4–6%
HbA1C (IFCC)B: 20–42 mmol/mol
Iron ♂S: 14–31 μmol/L
Iron ♀S: 11–30 μmol/L
Lactate (venous)P: 0.6–2.4 mmol/L
Lactate (arterial)P: 0.6–1.8 mmol/L
LDHP: 70–250 U/L
LHP: 3–16 U/L
MagnesiumP: 0.75–1.05 mmol/L
OsmolalityP: 278–305 mosmol/kg
PTHP: 0.8–8.5 pmol/L
PotassiumP: 3.5–5.3 mmol/L
Prolactin ♂P: <450 U/L
Prolactin ♀P: <600 U/L
PSAP: 0–4 mcg/mL
Protein (total)P: 60–80 g/L
Red cell folateB: 0.36–1.44 μmol/L
Renin (erect)P: 2.8–4.5 pmol/mL/h
Renin (recumbent)P: 1.1–2.7 pmol/mL/h
SodiumP: 135–145 mmol/L
TBGP: 7–17 mg/L
TSHP: 0.5–4.2 mU/L
T4P: 70–140 nmol/L
Free T4P: 9–22 pmol/L
TIBCS: 54–75 μmol/L
TriglyceridesP: 0.50–2.3 mmol/L
T3P: 1.2–3.0 nmol/L
Troponin TP: <0.1 mcg/L
Urate ♂P: 210–480 μmol/L
Urate ♀P: 150–390 μmol/L
UreaP: 2.5–6.7 mmol/L
Vitamin B12S: 0.13–0.68 nmol/L
Vitamin DS: 50 nmol/L
Arterial Blood Gases
pH7.35–7.45
PaCO₂4.7–6.0 kPa
PaO₂>10.6 kPa
Base excess±2 mmol/L
Urine
Cortisol (free)<280 nmol/24h
Hydroxyindole acetic acid16–73 μmol/24h
Hydroxymethylmandelic acid16–48 μmol/24h
Metanephrines0.03–0.69 μmol/mmol cr.
Osmolality350–1000 mosmol/kg
17-Oxogenic steroids ♂28–30 μmol/24h
17-Oxogenic steroids ♀21–66 μmol/24h
17-Oxosteroids ♂17–76 μmol/24h
17-Oxosteroids ♀14–59 μmol/24h
Phosphate (inorganic)15–50 mmol/24h
Potassium14–120 mmol/24h
Protein<150 mg/24h
Protein/creatinine ratio<3 mg/mmol
Sodium100–250 mmol/24h
Haematology
WCC4.0–11.0 ×10⁹/L
RBC ♂4.5–6.5 ×10¹²/L
RBC ♀3.9–5.6 ×10¹²/L
Hb ♂130–180 g/L
Hb ♀115–160 g/L
PCV ♂0.4–0.54 L/L
PCV ♀0.37–0.47 L/L
MCV76–96 fL
MCH27–32 pg
MCHC300–360 g/L
RDW11.6–14.6%
Neutrophils2.0–7.5 ×10⁹/L (40–75%)
Lymphocytes1.0–4.5 ×10⁹/L (20–45%)
Eosinophils0.04–0.44 ×10⁹/L (1–6%)
Basophils0–0.10 ×10⁹/L (0–1%)
Monocytes0.2–0.8 ×10⁹/L (2–10%)
Platelets150–400 ×10⁹/L
Reticulocytes0.8–2.0% / 25–100 ×10⁹/L
Prothrombin time10–14 s
APTT35–45 s
Paediatric
Pulse Rate (bpm)
Neonate140–160
Infant <1yr120–140
1–5 years110–130
5–12 years80–120
>12 years70–100
Respiratory Rate (tachypnoea)
0–2 months≥60/min
2–12 months≥50/min
1–5 years≥40/min
>5 years≥30/min
Blood Pressure (mmHg)
Term65/45
1 year75/50
4 years85/60
8 years95/65
10 years100/70
Weight Formulas
3–12 months(a + 9)/2 kg
1–6 years2a + 8 kg
>6 years(7a − 5)/2 kg
Haemoglobin (g/dL)
Term newborn13–20
1 month11–18
2 months10–15
1–2 years10–13
>2 years11–14
MUAC (6 months–5 years)
Obese>17.5 cm
Normal13.5–17.4 cm
At risk12.5–13.4 cm
Moderate malnutrition11.5–12.4 cm
Severe malnutrition<11.5 cm
Developmental Milestones
Social smile1.5 months
Head control4 months
Sits unsupported7 months
Crawls10 months
Stands unsupported10–12 months
Walks12–13 months
Talks18 months
CSF WBC (/mm³)
Term newborn0–25
>2 weeks0–5
Calculator ›

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