Seronegative spondyloarthropathies (spondyloarthritides) are a group of chronic inflammatory conditions that commonly affect the axial skeleton, lack rheumatoid factor and anti-CCP antibodies.
Diagnostic hallmarks of Seronegative spondyloarthropathies
| Feature | Description |
|---|---|
| Seronegativity | Rheumatoid factor and anti-CCP negative |
| Genetic association | HLA-B27 association – it codes for an MHC Class I molecule |
| Main sites involved | Axial arthritis (axial skeleton) – spine and sacroiliac joints |
| Other sites involved | Entheses (achilles tendonitis, plantar fasciitis), dactylitis, peripheral joints |
| Extra-articular manifestations | Anterior uveitis, psoriatic rash (psoriatic arthritis), oral ulcers, aortic valve incompetence, and inflammatory bowel disease |
- Seronegative spondyloarthritides (PAIR)
