TOTW #23 - Haematology Start QuizPage 1 of 28 Which of the following regarding hemostasis is false? Primary homeostasis results in formation of a red thrombus Secondary hemostasis results in formation of a fibrin clot Von Willebrand factor (vWF) in endothelial cells is stored in Weibel-Palade bodies vWF in platelets is stored in alpha-granules Page 2 of 28 Which of the following is not a component of dense granules of platelets? Serotonin Histamine Fibronectin Adenosine diphosphate (ADP) Page 3 of 28 Which of the following coagulation factors is not involved in the intrinsic pathway? XII XI X IX Page 4 of 28 Which of the following is a non-fibrin specific fibrinolytic agent? Alteplase Reteplase Tenecteplase Streptokinase Page 5 of 28 Deficiency of factor XI leads to the following condition: Haemophilia C Haemophilia B Haemophilia A Haemophilia D Page 6 of 28 A patient presented to the hematology clinic with splenomegaly, night sweats, painless lymphadenopathy and Pel-Ebstein fever. The following cells were seen under the microscope.Name the cells. What is your diagnosis? Lymphocytes, AML Neutrophils, Sickle cell disease Reed-Sternberg cells, Hodgkin's lymphoma Reed-Sternberg cells, Non-hodgkin's lymphoma Page 7 of 28 Which of the following conditions is characterized by a deficiency of the enzyme glucose-6-phosphate dehydrogenase (G6PD)? Sickle cell anemia Hereditary spherocytosis Glucose-6-phosphate dehydrogenase deficiency Thalassemia Page 8 of 28 Which of the following is the primary cause of iron deficiency anemia in adults? Decreased dietary intake of iron Chronic blood loss Increased hemolysis Vitamin B12 deficiency Page 9 of 28 Which of the following is the most common inherited bleeding disorder? Haemophilia A Haemophilia B Von Willebrand disease Disseminated intravascular coagulation (DIC) Page 10 of 28 Which of the following is the typical finding in the peripheral blood smear of a patient with multiple myeloma? Rouleaux formation Heinz bodies Howell-Jolly bodies Bite cells Page 11 of 28 Which of the following hematologic disorders is characterized by the presence of the Philadelphia chromosome (t(9;22) translocation)? Acute lymphoblastic leukemia (ALL) Chronic myelogenous leukemia (CML) Acute myeloid leukemia (AML) Chronic lymphocytic leukemia (CLL) Page 12 of 28 Which of the following is an indicator of good prognosis for pre-B childhood ALL? Age of diagnosis Hypodiploidy Hyperdiploidy WBC count Page 13 of 28 Which antibody is commonly elevated in Waldenstrom macroglobulinemia? IgG IgA IgM IgG Page 14 of 28 Red blood cells are prepared from whole blood by removing the plasma. Shelf life of whole blood is: 35 days 120 days 7 days 85 days Page 15 of 28 Deficiency of which of the following causes hereditary spherocytosis? Actin Glycoprotein Ankyrin G-6PD deficiency Page 16 of 28 A 37 yo male presents with severe fatigue, frequent nose bleeds, and gingival masses. The abnormal cells seen in the blood smear show tissue paper nuclei. What is the diagnosis? Acute myelogenous leukemia Acute monocytic leukemia Chronic lymphocytic leukemia Acute lymphocytic leukemia Page 17 of 28 A patient is found to have macrocytic anemia. What finding on peripheral blood smear shown below is highly suggestive of megaloblastosis? Hypochromic RBCs Polysegmented neutrophil Microcytic RBCs Macrocytic RBCs Page 18 of 28 Polycythemia vera is a disorder that results in: Underproduction of WBCs Underproduction of platelets Overproduction of RBCs Underproduction of RBCs Page 19 of 28 Which of the following is elevated in a polycythemia vera? Hemoglobin Erythropoetin Sodium Potassium Page 20 of 28 Which of the following is the gene involved in 95% of cases of polycythemia vera? c-KIT RAS Philadelphia chromosome JAK2 Page 21 of 28 Which of the following is true about polycythemia vera? Men are more frequently affected The peak incidence is in patients older than 75 years Hypohomocystinemia is a risk factor Severe dehydration cannot cause features similar to PV Page 22 of 28 Which of the following is correct about the presentation of polycythemia vera? Hepatomegaly is seen more frequently than splenomegaly Hypertension is not associated with PV Unexplained weight gain is common Pruritus after a warm shower Page 23 of 28 A 30 year old presents with abdominal distention and discomfort. on physical examination he is found to have massive splenomegaly extending into the iliac fossa. which of the following is the patient LEAST likely to be suffering from? Myelofibrosis Chronic myeloid leukemia Kalazar Bacterial endocarditis Page 24 of 28 Erythrocyte sedimentation rate is markedly elevated in the following except: Rheumatoid arthritis Abdominal tuberculosis Sickle cell disease Waldenstrom’s macroglobulinemia Page 25 of 28 Starry sky appearance is seen in: Hodgkin lymphoma Burkitt’s lymphoma Follicular lymphoma Small lymphocytic lymphoma Page 26 of 28 Molecular abnormalities associated with polycythemia vera: JAK 2 mutation BCL:ABL gene fusion t8:14 t9:22 Page 27 of 28 Which of the following is a long term complication of therapy with cytotoxic drugs: Neutrophilia Howell Jolly bodies Poly-segmented neutrophils Myelodysplasia Page 28 of 28 Below is a microscopic image of a sample taken from a mass that developed on the cheek of a 7 year old child. What is the diagnosis? Which micro-organism is most commonly associated with the given diagnosis? Burkitt's lymphoma, HPV Sickle cell anemia, CMV Acute myeloid leukemia, EBV Burkitt's lymphoma, EBV Multiple Authors | WebsiteTOTW #26 - MicrobiologyTOTW #25 - PsychiatryTOTW #24 - BiochemistryTOTW #22 - Embryology Previous Post A 46-year-old with right upper quadrant pain Next Post TOTW #24 - Biochemistry