Sickle Cell Disease

Updated on November 11, 2024 Overview Sickle cell disease is a hereditary, autosomal recessive disease caused by a point mutation of the beta-globin gene resulting in the absence of HbA and the production of HbS. Hbs has a preponderance to “sickling” (esp. during hypoxia, dehydration, acidosis). The primary concern for patients with sickle cell disease...