Pelvic Organ Prolapse

Last updated: November 17, 2025
Table Of Contents

Overview

Pelvic organ prolapse is an abdnormal herniation of pelvic organs from their normal anatomic position. It is the third most common reason for elective hysterectomy.

11% of women undergo surgery for prolapse or incontinence in their lifetime.

Levels of vaginal support

LevelStructureDefect
Level ICardinal and uterosacral ligaments. Holds theDefect leads to apical prolapse associated with uterine descent and enterocele
Level IIParavaginal attachments contiguous with cardinal and uterosacral complexDefect leads to lateral or paravaginal prolapse which is associated with cystocele
Leve IIIPerineal body, perineal musculature and connective tissue supporting the distal 1/3 of the vaginaDefect leads to anterior and posterior prolapse

Types of prolapse

DefectProlapse
Anterior vaginal wall prolapseCystocele or urethrocele or cystourethrocele
Lateral vaginal wall/ paravaginal prolapse (most common defect)Cystocele
Posterior vaginal wall prolapseRectocele (more distal) or enterocele (more proximal)
Apical vaginal wall prolapseEnetrocele or uterine prolapse

Grading of uterine prolapse

DegreeDescription
1st degreeCervix protrudes below its normal level on valsava
2nd degreeCervix protrudes from vulva on straining
3rd degree (complete procidentia)Whole uterus is completely prolapse outisde the vulva, even without valsava
  • Risk factors
    • Multiparity
    • Older age: decreased oestrogen decreases strength of ligaments
    • Other obstetric risk factors
      • Macrosomia
      • Prolonged second stage
      • Episiotomy
      • Lacerations
      • Epidural analegesia
      • Forceps use
    • Connective tissue disease e.g. Marfans and Ehler’s Danlos
    • Race: whites and hispanics > blacks and asians
    • Increased abdominal pressure e.g. chronic constipation
  • Pathophysiology
    • Pelvic floor support is provided by the levator ani (iliococcygeus, pubococcygeous, and puborectalis), fascia and ligaments
    • Direct damage to these structures or nerves can weaken the pelvic floor
    • Fascia and ligaments get weaker with age causing pelvic organ prolapse
  • Signs and symptoms
    • Bulge symptoms (more specific to pelvic organ prolapse)
      • Sensation of vaginal protrusion or pressure
      • “Heaviness”
    • Urinary symptoms
      • Stress incontinence
      • Urgency and Frequency
      • Weak or prolonged stream and hesitancy
      • Feeling of incomplete emptying
      • Difficulty with complete emptying
    • Bowel symptoms
      • Feeling of incomplete emptying
      • Incontinence
      • Digital evacuation
    • Sexual symptoms: dyspareunia
    • Pain: back pain, genital pain
  • Physical examination
    • Visual examination while standings, with and without valsava
    • Bimanual examination
    • Bivalve speculum examination
    • Split speculum examinaiton
    Note the anatomic position of the prolapsed portion Note the presence or absence of rugae on the prolapsed portion (rugae presents = lateral or paravaginal defect) Approximate the distance or extent of prolapse in relation to hymen
  • Investigations
    • Urodynamic testing (not required in most cases)
      • Cystometry: to measure pressure in the bladder during filling
      • Uroflowmetry: to measure volume and speed of urine flow over time
      • Pressure flow studies: to meausre the bladder pressure required to urinate and flow rate at a given pressure
    • Pelvic floor electromyography (EMG): to measure the electrical activity of muscles and detect neuromuscular abnormalities
    • Simple cystometrics: infuse saline or sterile water into the bladder and ask the patient to indicate when they feel the liquid, when their bladder feels full, and when they experience an urge to urinate
    • Pelvic floor ultrasound: trans-anal, trans-perineal, and vaginal view to capture images during coughing or straining to see how pelvic organs move
    • Anorectla manometry and defecography (proctography)
  • Non-surgical treatment
    • Pessary: first-line treatment for pelvic organ prolapse. Evaluate for vaginal atrophy prior to placement. Remove nightly to weekly
      • Ring pessary: for first and second degree prolapse
      • Gellhorn pessary: for third degree prolapse
    • Kegel exercise
  • Surgical treatment
    • Obliterative
    • Reconstructive
Reference Intervals
Biochemistry
ACTHP: <80 ng/L
ALTP: 5–35 U/L
AlbuminP: 35–50 g/L
AldosteroneP: 100–500 pmol/L
Alk. phosphataseP: 30–130 U/L
α-AmylaseP: 0–180 IU/dL
α-FetoproteinS: <10 kU/L
Angiotensin IIP: 5–35 pmol/L
ADHP: 0.9–4.6 pmol/L
ASTP: 5–35 U/L
BicarbonateP: 24–30 mmol/L
BilirubinP: 3–17 μmol/L
BNPP: <50 ng/L
CRPP: <10 mg/L
CalcitoninP: <0.1 mcg/L
Calcium (ionized)P: 1.0–1.25 mmol/L
Calcium (total)P: 2.12–2.60 mmol/L
ChlorideP: 95–105 mmol/L
CholesterolP: <5.0 mmol/L
VLDLP: 0.128–0.645 mmol/L
LDLP: <2.0 mmol/L
HDLP: 0.9–1.93 mmol/L
Cortisol AMP: 450–700 nmol/L
Cortisol MidnightP: 80–280 nmol/L
CK ♂P: 25–195 U/L
CK ♀P: 25–170 U/L
CreatinineP: 70–100 μmol/L
FerritinP: 12–200 mcg/L
FolateS: 2.1 mcg/L
FSHP: 2–8 U/L ♂; >25 menopause
GGT ♂P: 11–51 U/L
GGT ♀P: 7–33 U/L
Glucose (fasting)P: 3.5–5.5 mmol/L
Growth hormoneP: <20 mu/L
HbA1C (DCCT)B: 4–6%
HbA1C (IFCC)B: 20–42 mmol/mol
Iron ♂S: 14–31 μmol/L
Iron ♀S: 11–30 μmol/L
Lactate (venous)P: 0.6–2.4 mmol/L
Lactate (arterial)P: 0.6–1.8 mmol/L
LDHP: 70–250 U/L
LHP: 3–16 U/L
MagnesiumP: 0.75–1.05 mmol/L
OsmolalityP: 278–305 mosmol/kg
PTHP: 0.8–8.5 pmol/L
PotassiumP: 3.5–5.3 mmol/L
Prolactin ♂P: <450 U/L
Prolactin ♀P: <600 U/L
PSAP: 0–4 mcg/mL
Protein (total)P: 60–80 g/L
Red cell folateB: 0.36–1.44 μmol/L
Renin (erect)P: 2.8–4.5 pmol/mL/h
Renin (recumbent)P: 1.1–2.7 pmol/mL/h
SodiumP: 135–145 mmol/L
TBGP: 7–17 mg/L
TSHP: 0.5–4.2 mU/L
T4P: 70–140 nmol/L
Free T4P: 9–22 pmol/L
TIBCS: 54–75 μmol/L
TriglyceridesP: 0.50–2.3 mmol/L
T3P: 1.2–3.0 nmol/L
Troponin TP: <0.1 mcg/L
Urate ♂P: 210–480 μmol/L
Urate ♀P: 150–390 μmol/L
UreaP: 2.5–6.7 mmol/L
Vitamin B12S: 0.13–0.68 nmol/L
Vitamin DS: 50 nmol/L
Arterial Blood Gases
pH7.35–7.45
PaCO₂4.7–6.0 kPa
PaO₂>10.6 kPa
Base excess±2 mmol/L
Urine
Cortisol (free)<280 nmol/24h
Hydroxyindole acetic acid16–73 μmol/24h
Hydroxymethylmandelic acid16–48 μmol/24h
Metanephrines0.03–0.69 μmol/mmol cr.
Osmolality350–1000 mosmol/kg
17-Oxogenic steroids ♂28–30 μmol/24h
17-Oxogenic steroids ♀21–66 μmol/24h
17-Oxosteroids ♂17–76 μmol/24h
17-Oxosteroids ♀14–59 μmol/24h
Phosphate (inorganic)15–50 mmol/24h
Potassium14–120 mmol/24h
Protein<150 mg/24h
Protein/creatinine ratio<3 mg/mmol
Sodium100–250 mmol/24h
Haematology
WCC4.0–11.0 ×10⁹/L
RBC ♂4.5–6.5 ×10¹²/L
RBC ♀3.9–5.6 ×10¹²/L
Hb ♂130–180 g/L
Hb ♀115–160 g/L
PCV ♂0.4–0.54 L/L
PCV ♀0.37–0.47 L/L
MCV76–96 fL
MCH27–32 pg
MCHC300–360 g/L
RDW11.6–14.6%
Neutrophils2.0–7.5 ×10⁹/L (40–75%)
Lymphocytes1.0–4.5 ×10⁹/L (20–45%)
Eosinophils0.04–0.44 ×10⁹/L (1–6%)
Basophils0–0.10 ×10⁹/L (0–1%)
Monocytes0.2–0.8 ×10⁹/L (2–10%)
Platelets150–400 ×10⁹/L
Reticulocytes0.8–2.0% / 25–100 ×10⁹/L
Prothrombin time10–14 s
APTT35–45 s
Paediatric
Pulse Rate (bpm)
Neonate140–160
Infant <1yr120–140
1–5 years110–130
5–12 years80–120
>12 years70–100
Respiratory Rate (tachypnoea)
0–2 months≥60/min
2–12 months≥50/min
1–5 years≥40/min
>5 years≥30/min
Blood Pressure (mmHg)
Term65/45
1 year75/50
4 years85/60
8 years95/65
10 years100/70
Weight Formulas
3–12 months(a + 9)/2 kg
1–6 years2a + 8 kg
>6 years(7a − 5)/2 kg
Haemoglobin (g/dL)
Term newborn13–20
1 month11–18
2 months10–15
1–2 years10–13
>2 years11–14
MUAC (6 months–5 years)
Obese>17.5 cm
Normal13.5–17.4 cm
At risk12.5–13.4 cm
Moderate malnutrition11.5–12.4 cm
Severe malnutrition<11.5 cm
Developmental Milestones
Social smile1.5 months
Head control4 months
Sits unsupported7 months
Crawls10 months
Stands unsupported10–12 months
Walks12–13 months
Talks18 months
CSF WBC (/mm³)
Term newborn0–25
>2 weeks0–5
Calculator

Post Discussion

Your email address will not be published. Required fields are marked *