Overview Plasma cell disorders involve the abnormal proliferation of plasma cells. These B-cell clones synthesize and secrete a single monoclonal immunoglobulin or its fragments e.g. free light chains, and free…...
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Overview Lymphomas are tumors arising from lymphoid cells. They have a much less dramatic presentation than leukemias. They are classified into 2 major groups – Hodgkin’s and Non-Hodgkin’s – based…...
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Myelodysplastic syndromes are characterized by dysplastic and ineffective hematopoiesis – bone marrow failure**.** It is sometimes described as “pre-leukemic” since there is a risk of transformation into acute leukemia (30%).…...
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Overview Myeloproliferative neoplasms are abnormal proliferations of one or more terminal myeloid cell lines in the peripheral blood (RBCs, WBCs, platelets). Myeloproliferative neoplasms are poorly characterized and poorly undersood. They…...
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CLL is characterized by a progressive accumulation of monoclonal, mature, non-functional B lymphocytes. CLL is usually discovered on routine blood tests as an isolated lymphocytosis. It is defined by a…...
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Overview Acute Leukemia is an abnormal proliferation of blasts in either the peripheral myeloid or lymphoid cell lines. Acute Leukemias are of rapid onset. The blasts dramatically affect the bone…...
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Hematological malignancies are clonal diseases (neoplasms) that are derived from a single hematopoietic stem cell or peripheral lymphoid tissue that has undergone a genetic alteration (e.g. B cell Lymphoma)… Hyperexcision…...
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Overview Sickle cell disease is a hereditary, autosomal recessive disease caused by a point mutation of the beta-globin gene resulting in the absence of HbA and the production of HbS.…...
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Overview Hemolytic anemia is simply anemia due to the destruction of red blood cells. The destruction of red blood cells happens at an accelerated pace, beyond the capacity of the…...
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Overview Macrocytic anemia is characterized by Low Hb and High MCV (> 100). B12 and folate are required for the maturation of RBCs. Immature RBCs are larger, hence the increase…...
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