Dr Jeffrey Kalei

Dr Jeffrey Kalei

Author and illustrator for Hyperexcision. Interested in emergency room medicine. I have a passion for medical education and drawing.

Inhalants

Inhalants represent a broad group of drugs which are inhaled and absorbed through the lungs. They are generally CNS depressants. Intoxication lasts 15-30 minutes and may be sustained with repeated use. An overdose may be fatal due to respiratory depression…

Nicotine

Nicotine is derived from the tobacco plant. It stimulates nicotinic receptors in autonomic ganglia and is highly addictive due to its effects on the dopaminergic system. It also has prominent withdrawal symptoms. Nicotine use is not an acute problem. The…

Cannabis

Cannabis is the most commonly used illicit drug in the world. Intoxication is usually an incidental finding on a urine toxicology screen. The main active ingredient in cannabis is tetrahydrocannabinol (THC), which acts on cannabinoid receptors in the brain. Cannabinoid…

Opioids

Opioids bind to opiate receptors (mu, kappa, and delta), which are involved in analgesia, sedation, and dependence. They are commonly administered intravenously (appear as needle marks forming a track on physical exam) or inhaled (increasingly smoked with cannabis nowadays). Most…

Hallucinogens

Hallucinogens Hallucinogens work through various mechanisms. They have no addiction profile and no withdrawal syndromes, though patients taking LSD may experience “flashbacks” (recurrent intoxication) later in life. Their tolerance is very low. Examples include: Lysergic acid diethylamide (LSD) Mescaline (Peyote…

Alcohol

Alcoholism Alcohol is the most significant, most commonly used, and most commonly abused drug. Intoxication is measured with blood alcohol concentration (BAC). It is a depressant (contrary to popular belief that it is a stimulant, as it can ultimately cause…

Bipolar Disorder

Bipolar Disorder Bipolar disorder is characterized by recurrent mood disturbance mixed with mania/hypomania + depression. Thought to be a bridge between unipolar depression and Schizophrenia spectrum disorders. The genetic link in Bipolar disorder is stronger than that of Unipolar depression,…

Depression

Major Depressive Disorder (Unipolar Depression) Depression is a very common condition associated with significant dysfunction. It is usually underdiagnosed and often chronic or recurrent. It commonly presents in patients with other general medical conditions. Multiple safe and effective treatment options…

Psychotherapies

Overview Psychotherapy is the use of communication and language to help patients understand their thoughts, feelings, and actions to bring about positive change. It is based on the communication between a therapist (psychologist or psychiatrist) and a patient. Historical Psychotherapies…

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