Dr Jeffrey Kalei

Choledochal cysts are cystic lesions of the biliary tree. Its clinical and laboratory findings are similar to biliary atresia.

Biliary atresia is a progressive fibro-inflammatory obliteration of the lumen of the biliary tree. It causes conjugated hyperbilirubinaemia, since there are defects in the biliary tract, resulting in cholestasis. The conjugated bilirubin is reabsorbed into the bloodstream, causing a direct…

Neonatal hepatitis is inflammation of the liver that results in jaundice, poor growth, and an enlarged liver. It can be a congenital or an early-acquired infection. This infection leads to direct hyperbilirubinaemia. Organisms can be transmitted transplacentally, via cervical ascent,…

Dubin-Johnson syndrome is an autosomal recessive condition that is caused by a mutation of the MRP2 channel, which transports conjugated bilirubin into the bile canaliculi. It results in conjugated hyperbilirubinaemia. It is typically asymptomatic and usually presents in teenage years…

Criggler-Najjar syndrome is caused by a deficiency or absence of UDP-glucuronosyltransferase (UGT1A1), which leads to unconjugated hyperbilirubinaemia. Types of Criggler-Najjar Syndrome Type Description Criggler-Najjar Type I Absence of UGT1A1, resulting in inability to conjugate bilirubin (Indirect hyperbilirubinemia). It does not…

ABO incompatibility is caused by maternal anti-ABO antibodies attacking fetal RBCs, causing hemolysis. It is more common, but less severe than Rh incompatibility – the majority of cases are clinically undetectable. 20% of all pregnancies are of a type O…

Rhesus incompatibility results from maternal anti-Rh antibodies binding to fetal RBCs, causing hemolysis. It ranges from moderate hemolytic anaemia to hydrops fetalis (stillbirth) Definition of terms Term Definition Erythroblastosis fetalis This is a life-threatening anaemia due to severe hemolysis. It…