Ankylosing spondylitis is an autoimmune seronegative spondyloarthopathy that affects the axial skeleton and joints (shoulder and hip). It is HLA-B27 positive. It is more predominant in young men (under the age of 40), with a male-to-female ratio of 4:1.
Enteric arthritis is a seronegative spondyloarthopathy associated with gastrointestinal disease. Joint symptoms may precede bowel disease, occur simultaneously, or develop years later.
Reactive arthritis is a rare systemic inflammatory condition that follows gastrointestinal and urogenital infections. It presents with the triad of urethritis, conjunctivitis, and arthritis – “Can’t pee, can’t see, can’t climb a tree”. It is part of the seronegative spondyloarthropathies.
Psoriatic arthropathy is a chronic inflammatory, seronegative spondyloarthopathy associated with psoriasis. It occurs in 10-40% of patients with psoriasis and can present without skin changes. Classification of Psoriatic Arthropathy Classification Description Oligoarthritis Affects less than 5 joints and tends to be asymmetrical. This…
Seronegative spondyloarthropathies (spondyloarthritides) are a group of chronic inflammatory conditions that commonly affect the axial skeleton, lack rheumatoid factor and anti-CCP antibodies. Diagnostic hallmarks of Seronegative spondyloarthropathies Feature Description Seronegativity Rheumatoid factor and anti-CCP negative Genetic association HLA-B27 association –…
Infantile seborrhoeic dermatitis presents as erythematous patches with greasy scales in the scalp, face, and intertriginous zones.
Seborrhoeic dermatitis is a chronic/relapsing dermatitis that affects the sebaceous glands of the scalp, face, and trunk. It presents as erythematous plaques with greasy, yellowish scales. Malassezia yeast colonisation plays a role in the development of seborrhoeic dermatitis, alongside genetic…
Scabies is caused by the arachnid mite Sarcoptes scabiei. It commonly affects children and young adults, and is spread by prolonged skin contact.
Porphyria cutanea tarda is a blistering cutaneous photosensitivity. It is the most common porphyria. It is caused by a defect in uroporphyrinogen decarboxylase or hepatic damage.
Pompholyxis is a type of eczema that affects the hands and feet. It presents as pruritic vesicles affecting the palms (cheiropompholyx) and the feet (pedopompholyx)
