Advanced Cardiac Life Support

Last updated: March 9, 2026

Overview

  • Advanced Cardiac Life Support (ACLS) Team
    • Leader: older physician, orders medications, administers defibrillation as necessary, delegates role
    • Intubator: a physician with experience in placing ET tube
    • Thinker: a physician who can identify the possible underlying cause
    • IV nurse: nurse or trained professional to administer IV meds
    • CPR givers: anyone trained in CPR, preferably at least two people (one for pumping, the other for masking)

Cardiac Arrest

Refers to sudden loss of pulse, drop in blood pressure, and loss of perfusion. Death results in 5 minutes without proper resuscitation (but brain damage results earlier than this). This is a medical emergency. Can be idiopathic. Basic appearance, BMP, and history should clue you in.

Cardiopulmonary Resuscitation (CPR)

The first step is to initiate CPR

  • CPR (30 and 2)
    • 30 strong chest pumps (”Stayin’ Alive” – 100-120 bpm, 2 inches deep)
    • 2 rescue breaths (look for symmetrical chest rise)
    • Ensure full chest recoil during pumps!
    • Someone qualified should meanwhile be attempting to place an airway (endotracheal tube)

Reading the EKG

While CPR is being administered, someone should be reading the EKG.

The first thing to do is to determine whether or not the rhythm is “shockable”. Shockable rhythms may convert to non-shockable rhythm or vice versa so keep watch of the EKG.

  • Shockable rhythm
    • Ventricular Fibrillation (V-Fib)
    • Ventricular Tachycardia (V-Tach)
  • Non-shockable rhythms
    • Pulseless electrical activity (PEA; any rhythm apart from V-fib, V-tach, and asystole occurring without a pulse)
    • Asystole

Cardioversion (V-fib or Pulseless V-Tach)

If you have a shockable rhythm, switch the defibrillator to non-synchronized then deliver a shock.

  • Monomorphic V-Tach
    • Start with 100 J on the first attempt → 200 J → 300 J
  • Polymorphic V-tach
    • 360 J if monophasic device
    • 200 J if biphasic device (or unsure)

First round

Warm resuscitator then deliver a shock. Assess for pulse, and rhythm, and resume CPR (30/2) immediately if necessary.

Second round

If there is still no pulse, administer IV epinephrine 1mg (q 3-5 minutes). Shock. Check for pulse, and rhythm, and resume CPR (30/2) if necessary

Third round

If there is still no pulse administer IV epinephrine 1mg (3-5 mins after the previous dose)

Consider IV amiodarone 300mg or IV magnesium 2 (over 1-2 minutes). Amiodarone > Lidocaine. Can repeat amiodarone in subsequent rounds at 150 mg.

Shock. Check for pulse, and rhythm, and resume CPR (30/2) if necessary, repeat.

Asystole or Pulseless Electrical Activity (PEA)

Non-shockable rhythm. During CPR, administer IV epinephrine 1mg and IV atropine 1mg (if asystole or bradycardic PEA).

Repeat epinephrine every 3-5 mins. Atropine may be given up to 3 mg. Every 3-5 mins, check pulse/rhythm.

Post-resuscitation

If resuscitation is successful transfer the patient to an ICU. House elementary and proper ventilation is mandatory. Intensely monitor the patient over the next 24-48 hours.

Do a full physical exam, and check ribs for trauma from CPR (imaging)

Labs to get: Serial CMP, CBC, Cardiac enzymes

CXR and other diagnostic tests as necessary based on the patient’s state.

Reference Intervals
Biochemistry
ACTHP: <80 ng/L
ALTP: 5–35 U/L
AlbuminP: 35–50 g/L
AldosteroneP: 100–500 pmol/L
Alk. phosphataseP: 30–130 U/L
α-AmylaseP: 0–180 IU/dL
α-FetoproteinS: <10 kU/L
Angiotensin IIP: 5–35 pmol/L
ADHP: 0.9–4.6 pmol/L
ASTP: 5–35 U/L
BicarbonateP: 24–30 mmol/L
BilirubinP: 3–17 μmol/L
BNPP: <50 ng/L
CRPP: <10 mg/L
CalcitoninP: <0.1 mcg/L
Calcium (ionized)P: 1.0–1.25 mmol/L
Calcium (total)P: 2.12–2.60 mmol/L
ChlorideP: 95–105 mmol/L
CholesterolP: <5.0 mmol/L
VLDLP: 0.128–0.645 mmol/L
LDLP: <2.0 mmol/L
HDLP: 0.9–1.93 mmol/L
Cortisol AMP: 450–700 nmol/L
Cortisol MidnightP: 80–280 nmol/L
CK ♂P: 25–195 U/L
CK ♀P: 25–170 U/L
CreatinineP: 70–100 μmol/L
FerritinP: 12–200 mcg/L
FolateS: 2.1 mcg/L
FSHP: 2–8 U/L ♂; >25 menopause
GGT ♂P: 11–51 U/L
GGT ♀P: 7–33 U/L
Glucose (fasting)P: 3.5–5.5 mmol/L
Growth hormoneP: <20 mu/L
HbA1C (DCCT)B: 4–6%
HbA1C (IFCC)B: 20–42 mmol/mol
Iron ♂S: 14–31 μmol/L
Iron ♀S: 11–30 μmol/L
Lactate (venous)P: 0.6–2.4 mmol/L
Lactate (arterial)P: 0.6–1.8 mmol/L
LDHP: 70–250 U/L
LHP: 3–16 U/L
MagnesiumP: 0.75–1.05 mmol/L
OsmolalityP: 278–305 mosmol/kg
PTHP: 0.8–8.5 pmol/L
PotassiumP: 3.5–5.3 mmol/L
Prolactin ♂P: <450 U/L
Prolactin ♀P: <600 U/L
PSAP: 0–4 mcg/mL
Protein (total)P: 60–80 g/L
Red cell folateB: 0.36–1.44 μmol/L
Renin (erect)P: 2.8–4.5 pmol/mL/h
Renin (recumbent)P: 1.1–2.7 pmol/mL/h
SodiumP: 135–145 mmol/L
TBGP: 7–17 mg/L
TSHP: 0.5–4.2 mU/L
T4P: 70–140 nmol/L
Free T4P: 9–22 pmol/L
TIBCS: 54–75 μmol/L
TriglyceridesP: 0.50–2.3 mmol/L
T3P: 1.2–3.0 nmol/L
Troponin TP: <0.1 mcg/L
Urate ♂P: 210–480 μmol/L
Urate ♀P: 150–390 μmol/L
UreaP: 2.5–6.7 mmol/L
Vitamin B12S: 0.13–0.68 nmol/L
Vitamin DS: 50 nmol/L
Arterial Blood Gases
pH7.35–7.45
PaCO₂4.7–6.0 kPa
PaO₂>10.6 kPa
Base excess±2 mmol/L
Urine
Cortisol (free)<280 nmol/24h
Hydroxyindole acetic acid16–73 μmol/24h
Hydroxymethylmandelic acid16–48 μmol/24h
Metanephrines0.03–0.69 μmol/mmol cr.
Osmolality350–1000 mosmol/kg
17-Oxogenic steroids ♂28–30 μmol/24h
17-Oxogenic steroids ♀21–66 μmol/24h
17-Oxosteroids ♂17–76 μmol/24h
17-Oxosteroids ♀14–59 μmol/24h
Phosphate (inorganic)15–50 mmol/24h
Potassium14–120 mmol/24h
Protein<150 mg/24h
Protein/creatinine ratio<3 mg/mmol
Sodium100–250 mmol/24h
Haematology
WCC4.0–11.0 ×10⁹/L
RBC ♂4.5–6.5 ×10¹²/L
RBC ♀3.9–5.6 ×10¹²/L
Hb ♂130–180 g/L
Hb ♀115–160 g/L
PCV ♂0.4–0.54 L/L
PCV ♀0.37–0.47 L/L
MCV76–96 fL
MCH27–32 pg
MCHC300–360 g/L
RDW11.6–14.6%
Neutrophils2.0–7.5 ×10⁹/L (40–75%)
Lymphocytes1.0–4.5 ×10⁹/L (20–45%)
Eosinophils0.04–0.44 ×10⁹/L (1–6%)
Basophils0–0.10 ×10⁹/L (0–1%)
Monocytes0.2–0.8 ×10⁹/L (2–10%)
Platelets150–400 ×10⁹/L
Reticulocytes0.8–2.0% / 25–100 ×10⁹/L
Prothrombin time10–14 s
APTT35–45 s
Paediatric
Pulse Rate (bpm)
Neonate140–160
Infant <1yr120–140
1–5 years110–130
5–12 years80–120
>12 years70–100
Respiratory Rate (tachypnoea)
0–2 months≥60/min
2–12 months≥50/min
1–5 years≥40/min
>5 years≥30/min
Blood Pressure (mmHg)
Term65/45
1 year75/50
4 years85/60
8 years95/65
10 years100/70
Weight Formulas
3–12 months(a + 9)/2 kg
1–6 years2a + 8 kg
>6 years(7a − 5)/2 kg
Haemoglobin (g/dL)
Term newborn13–20
1 month11–18
2 months10–15
1–2 years10–13
>2 years11–14
MUAC (6 months–5 years)
Obese>17.5 cm
Normal13.5–17.4 cm
At risk12.5–13.4 cm
Moderate malnutrition11.5–12.4 cm
Severe malnutrition<11.5 cm
Developmental Milestones
Social smile1.5 months
Head control4 months
Sits unsupported7 months
Crawls10 months
Stands unsupported10–12 months
Walks12–13 months
Talks18 months
CSF WBC (/mm³)
Term newborn0–25
>2 weeks0–5
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