Neonatal Resuscitation

Neonates delivered with apnoea require resuscitation. Effective resuscitation can prevent most neonatal deaths at birth. The first 60 seconds are the most critical (golden minute) – positive pressure ventilation should be started during this period.

Definition of terms

TermDefinition
Primary apnoeaCessation of breathing and bradycardia due to a significant lack of oxygenation before or during delivery. This responds to simple stimulation, and the baby may resume breathing.
Secondary (terminal) apnoeaA more severe phase of apnoea after prolonged hypoxia. It is characterised by cessation of breathing and bradycardia (often < 60 bpm). This requires active resuscitation.
  • Summary of neonatal resuscitation
    • Warm, dry, stimulate
    • Ventilation is the most important step; most babies improve with positive pressure ventilation alone
    • Chest rise = effective ventilation
    • HR < 100 → ventilation
    • HR < 60 → chest compressions
    • HR persists < 60 → adrenaline
  • Preparation
    • Gather information
      • Expecting twins
      • Preterm or small
      • Maternal infection
      • Prolonged labour
      • Bleeding
      • Evidence of meconium
    • Prepare the room
      • Warm and free from draughts
      • Switch on the radiant warmer
      • Good light source
      • Flat firm surface with warm, clean towels
    • Equipment
      • Self-inflating bag
      • Masks
      • Stethoscope
      • Clock
      • Clean ties and scissors to cut the cord
    • Wash your hands and put on gloves
  • Components of neonatal resuscitation
    • Keeping the baby warm
      • Remove wet towels
      • Stimulate by rubbing the back
      • Wrap in warm, dry cloth
      • Initiate skin-to-skin contact with the mother if stable
    • Assessing the baby:
      • Assess the colour, tone, breathing, and heart rate (HR).
      • A normal baby should have regular breathing, good colour, good tone and HR above 100 breaths per minute.
      • A compromised baby will not breathe (or will be gasping), will be floppy, will have blue or pale lips and tongue, and bradycardia of < 100bpm.
      • Keep the baby below the placenta and delay cord clamping (1-3 minutes) if the baby is well to allow placental transfusion and prevent newborn anaemia.
      • Early cord clamping (< 1 minute) should be done for infants who are not breathing or have bradycardia < 100 bpm.
    • Opening the airway and breathing:
      • Open the airway by keeping it in a neutral position using head tilt (the neck should not be flexed or extended).
      • A folded towel can be placed below the shoulders to achieve this position.
      • Give 5 inflation breaths if the baby is not breathing or if there is bradycardia of < 100 – the lung is only inflated if the chest is moving.
        • Count out loud to keep an accurate rhythm – 1 2 3, 2 2 3, 3 2 3, 4 2 3.
      • Usually, all that is needed is to keep the head in a neutral position and give 5 inflation breaths.
      • Once the baby starts breathing, return them to the mother to be kept skin-to-skin.
      • Monitor respirations regularly and keep under observation for 6 hours.
    • Chest compressions
      • Give chest compressions if there is bradycardia of < 60 bpm after 30 seconds of effective ventilation
      • Encircle the chest with both hands, with the fingers supporting the spine.
      • 3 chest compressions to one breath
      • Reassess after 60 seconds
        • HR ≥ 60 bpm → stop compressins
        • HR < 60 bpm → continue and give drugs
    • Medications
      • Adrenaline if HR < 60 bpm despite effective ventilation and chest compressions
      • Volume expansion if blood loss or shock is suspected
Reference Intervals
Biochemistry
ACTHP: <80 ng/L
ALTP: 5–35 U/L
AlbuminP: 35–50 g/L
AldosteroneP: 100–500 pmol/L
Alk. phosphataseP: 30–130 U/L
α-AmylaseP: 0–180 IU/dL
α-FetoproteinS: <10 kU/L
Angiotensin IIP: 5–35 pmol/L
ADHP: 0.9–4.6 pmol/L
ASTP: 5–35 U/L
BicarbonateP: 24–30 mmol/L
BilirubinP: 3–17 μmol/L
BNPP: <50 ng/L
CRPP: <10 mg/L
CalcitoninP: <0.1 mcg/L
Calcium (ionized)P: 1.0–1.25 mmol/L
Calcium (total)P: 2.12–2.60 mmol/L
ChlorideP: 95–105 mmol/L
CholesterolP: <5.0 mmol/L
VLDLP: 0.128–0.645 mmol/L
LDLP: <2.0 mmol/L
HDLP: 0.9–1.93 mmol/L
Cortisol AMP: 450–700 nmol/L
Cortisol MidnightP: 80–280 nmol/L
CK ♂P: 25–195 U/L
CK ♀P: 25–170 U/L
CreatinineP: 70–100 μmol/L
FerritinP: 12–200 mcg/L
FolateS: 2.1 mcg/L
FSHP: 2–8 U/L ♂; >25 menopause
GGT ♂P: 11–51 U/L
GGT ♀P: 7–33 U/L
Glucose (fasting)P: 3.5–5.5 mmol/L
Growth hormoneP: <20 mu/L
HbA1C (DCCT)B: 4–6%
HbA1C (IFCC)B: 20–42 mmol/mol
Iron ♂S: 14–31 μmol/L
Iron ♀S: 11–30 μmol/L
Lactate (venous)P: 0.6–2.4 mmol/L
Lactate (arterial)P: 0.6–1.8 mmol/L
LDHP: 70–250 U/L
LHP: 3–16 U/L
MagnesiumP: 0.75–1.05 mmol/L
OsmolalityP: 278–305 mosmol/kg
PTHP: 0.8–8.5 pmol/L
PotassiumP: 3.5–5.3 mmol/L
Prolactin ♂P: <450 U/L
Prolactin ♀P: <600 U/L
PSAP: 0–4 mcg/mL
Protein (total)P: 60–80 g/L
Red cell folateB: 0.36–1.44 μmol/L
Renin (erect)P: 2.8–4.5 pmol/mL/h
Renin (recumbent)P: 1.1–2.7 pmol/mL/h
SodiumP: 135–145 mmol/L
TBGP: 7–17 mg/L
TSHP: 0.5–4.2 mU/L
T4P: 70–140 nmol/L
Free T4P: 9–22 pmol/L
TIBCS: 54–75 μmol/L
TriglyceridesP: 0.50–2.3 mmol/L
T3P: 1.2–3.0 nmol/L
Troponin TP: <0.1 mcg/L
Urate ♂P: 210–480 μmol/L
Urate ♀P: 150–390 μmol/L
UreaP: 2.5–6.7 mmol/L
Vitamin B12S: 0.13–0.68 nmol/L
Vitamin DS: 50 nmol/L
Arterial Blood Gases
pH7.35–7.45
PaCO₂4.7–6.0 kPa
PaO₂>10.6 kPa
Base excess±2 mmol/L
Urine
Cortisol (free)<280 nmol/24h
Hydroxyindole acetic acid16–73 μmol/24h
Hydroxymethylmandelic acid16–48 μmol/24h
Metanephrines0.03–0.69 μmol/mmol cr.
Osmolality350–1000 mosmol/kg
17-Oxogenic steroids ♂28–30 μmol/24h
17-Oxogenic steroids ♀21–66 μmol/24h
17-Oxosteroids ♂17–76 μmol/24h
17-Oxosteroids ♀14–59 μmol/24h
Phosphate (inorganic)15–50 mmol/24h
Potassium14–120 mmol/24h
Protein<150 mg/24h
Protein/creatinine ratio<3 mg/mmol
Sodium100–250 mmol/24h
Haematology
WCC4.0–11.0 ×10⁹/L
RBC ♂4.5–6.5 ×10¹²/L
RBC ♀3.9–5.6 ×10¹²/L
Hb ♂130–180 g/L
Hb ♀115–160 g/L
PCV ♂0.4–0.54 L/L
PCV ♀0.37–0.47 L/L
MCV76–96 fL
MCH27–32 pg
MCHC300–360 g/L
RDW11.6–14.6%
Neutrophils2.0–7.5 ×10⁹/L (40–75%)
Lymphocytes1.0–4.5 ×10⁹/L (20–45%)
Eosinophils0.04–0.44 ×10⁹/L (1–6%)
Basophils0–0.10 ×10⁹/L (0–1%)
Monocytes0.2–0.8 ×10⁹/L (2–10%)
Platelets150–400 ×10⁹/L
Reticulocytes0.8–2.0% / 25–100 ×10⁹/L
Prothrombin time10–14 s
APTT35–45 s
Paediatric
Pulse Rate (bpm)
Neonate140–160
Infant <1yr120–140
1–5 years110–130
5–12 years80–120
>12 years70–100
Respiratory Rate (tachypnoea)
0–2 months≥60/min
2–12 months≥50/min
1–5 years≥40/min
>5 years≥30/min
Blood Pressure (mmHg)
Term65/45
1 year75/50
4 years85/60
8 years95/65
10 years100/70
Weight Formulas
3–12 months(a + 9)/2 kg
1–6 years2a + 8 kg
>6 years(7a − 5)/2 kg
Haemoglobin (g/dL)
Term newborn13–20
1 month11–18
2 months10–15
1–2 years10–13
>2 years11–14
MUAC (6 months–5 years)
Obese>17.5 cm
Normal13.5–17.4 cm
At risk12.5–13.4 cm
Moderate malnutrition11.5–12.4 cm
Severe malnutrition<11.5 cm
Developmental Milestones
Social smile1.5 months
Head control4 months
Sits unsupported7 months
Crawls10 months
Stands unsupported10–12 months
Walks12–13 months
Talks18 months
CSF WBC (/mm³)
Term newborn0–25
>2 weeks0–5
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