Proximal Humerus Fracture

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Proximal Humerus Fracture

The most common fracture pattern of the proximal humerus is a transverse fracture. Most fractures are non-displaced and are treated non-operatively.

It has a bimodal distribution. 70% of cases occur in women. It is the 3rd most common fracture in the elderly, typically occurring after a fall.

Neer’s classification of proximal humerus fracture

The proximal humerus is divided into 4 fragments:

  1. Head/articular surface
  2. Greater tuberosity
  3. Lesser tuberosity
  4. Humeral shaft

Fragments are considered separate parts if they are displaced > 1 cm (10 mm) or > 45 degrees of angulation. Some use 0.5 cm (5mm) as a measure of displacement.

2-part fractures

FractureDescriptionTreatment
Surgical neck fractureMost common pattern. The shaft is pulled anteriorly and medially by the pectoralis majorClosed reduction and sling. Operative treatment with CRPP, ORIF, and IM nail
Greater tuberosityThe greater trochanter is pulled superiorly and posteriorly by the rotator cuffNon-operative treatment if displaced < 5mm. Operative treatment if displaced > 5mm
Lesser tuberosityAssociated with the forceful impaction of the humeral head against the glenoid cavity during posterior dislocation.Non-operative treatment
Anatomical neckRareNon-operative treatment for minimally displaced. ORIF in young patients. ORIF, hemiarthroplasty, or reverse total shoulder arthroplasty in the elderly

3-part fracture

FractureDescriptionTreatment
Surgical neck and greater trochanterThe articular fragment is internally rotatedNon-operative treatment for minimally displaced fractures. Operative treatment in young patients. Arthroplasty in elderly patients.
Surgical neck and lesser trochanterThe articular surface is pulled anteriorly by the rotator cuffNon-operative treatment. Operative treatment in young patients. Arthroplasty in elderly patients.

4-Part fracture

FractureDescriptionTreatment
Valgus impactedThere is alignment between the medial shaft and head segment on X-rayOperative treatment
4-part with head-splittting fractureHas a high risk of avascular necrosis. The shaft is pulled medially by the pectoralis majorOperative treatment
  • Risk factors
  • Mechanism of injury
    • Falling onto an outstretched hand (FOOSH) from a standing height in older osteoporotic patients
    • High-energy trauma, e.g., MVA in young patients
    • Excessive shoulder abduction in individuals with osteoporosis
    • Direct trauma
    • Electric shock or seizure
    • Pathologic fracture (malignant or benign process)
  • Associated injuries
    • Axillary nerve injury
    • Arterial injury
  • Signs and symptoms
    • Shoulder pain
    • Swelling
    • Tenderness
    • Painful active/passive and decreased range of motion
    • Signs of brachial plexus and axillary nerve injury
    • Ecchymoses over the upper arm and chest
  • Physical examination
    • Axillary nerve damage
      • Check for arm abduction and palpate the radial nerve
      • Check for numbness over the regimental patch
  • Investigation
    • XR affected shoulder (AP, Scapular Y-view, and axillary view)
      • Pseudosubluxation due to muscle atony and blood in the capsule
    • CT scan: for pre-operative planning, intra-articular comminuted fractures, or concern for head-split fracture
    • MRI: for associated rotator cuff injury
  • Indications for non-operative treatment
    • Minimally displaced surgical and anatomic neck fractures
    • Greater tuberosity fracture < 5mm displaced
  • Indications for operative treatment
    • 2-part surgical neck fracture
    • Greater tuberosity fracture > 5mm displaced (will lead to impingement and loss of abduction)
    • 3-part and 4-part fractures in young patients
    • Head-split fracture in young patients
  • Non-operative treatment
    • Sling immobilization for 2 – 3 weeks
    • Immediate physiotherapy for early range of motion exercises
  • Operative treatment
  • Complications
    • Avascular necrosis: less frequent than in lower extremity fractures
    • Neurologic injury: involves the axillary nerve, subscapular nerve, or musculocutaneous nerve
    • Malunion: commonly varus apex-anterior or malunion of the greater trochanter
    • Non-union: commonly affects a 2-part surgical neck fracture
    • Rotator cuff injury
    • Injury to the long head of the biceps tendon
    • Missed posterior dislocation (should be considered in patients with lesser tuberosity fracture)
    • Adhesive capsulitis
    • Post-traumatic arthritis
    • Infection

Proximal Humerus Fracture Malunion

Defined as malposition of humeral tuberosities: rotation, angulation, and/or offset of the head-shaft junction, or articular incongruities

  • Risk Factors
  • Signs and symptoms
    • Pain and weakness
    • Limited range of motion
  • Physical examination
    • Muscle atrophy
    • Diffuse tenderness
    • Blocks in the range of motion or crepitus in both active and passive movement
    • Weakness in abduction and external rotation (greater tuberosity malunion)
    • Weakness in internal rotation (lesser tuberosity malunion)
    • Instability (positive apprehension test in humeral head malunion)
  • Investigations
    • X-ray (AP, scapular Y, and axillary view)
      • Neck shaft angle- in varus or valgus (<120 or >150)
      • Greater tuberosity superiorly and posteriorly displaced, externally rotated (>1cm from native anatomical position)
      • Lesser tuberosity medially displaced (>1cm from native anatomical position)
  • Non-operative treatment
    • NSAIDs
    • Physical therapy
    • Occasional corticosteroid therapy
  • Operative treatment
Reference Intervals
Biochemistry
ACTHP: <80 ng/L
ALTP: 5–35 U/L
AlbuminP: 35–50 g/L
AldosteroneP: 100–500 pmol/L
Alk. phosphataseP: 30–130 U/L
α-AmylaseP: 0–180 IU/dL
α-FetoproteinS: <10 kU/L
Angiotensin IIP: 5–35 pmol/L
ADHP: 0.9–4.6 pmol/L
ASTP: 5–35 U/L
BicarbonateP: 24–30 mmol/L
BilirubinP: 3–17 μmol/L
BNPP: <50 ng/L
CRPP: <10 mg/L
CalcitoninP: <0.1 mcg/L
Calcium (ionized)P: 1.0–1.25 mmol/L
Calcium (total)P: 2.12–2.60 mmol/L
ChlorideP: 95–105 mmol/L
CholesterolP: <5.0 mmol/L
VLDLP: 0.128–0.645 mmol/L
LDLP: <2.0 mmol/L
HDLP: 0.9–1.93 mmol/L
Cortisol AMP: 450–700 nmol/L
Cortisol MidnightP: 80–280 nmol/L
CK ♂P: 25–195 U/L
CK ♀P: 25–170 U/L
CreatinineP: 70–100 μmol/L
FerritinP: 12–200 mcg/L
FolateS: 2.1 mcg/L
FSHP: 2–8 U/L ♂; >25 menopause
GGT ♂P: 11–51 U/L
GGT ♀P: 7–33 U/L
Glucose (fasting)P: 3.5–5.5 mmol/L
Growth hormoneP: <20 mu/L
HbA1C (DCCT)B: 4–6%
HbA1C (IFCC)B: 20–42 mmol/mol
Iron ♂S: 14–31 μmol/L
Iron ♀S: 11–30 μmol/L
Lactate (venous)P: 0.6–2.4 mmol/L
Lactate (arterial)P: 0.6–1.8 mmol/L
LDHP: 70–250 U/L
LHP: 3–16 U/L
MagnesiumP: 0.75–1.05 mmol/L
OsmolalityP: 278–305 mosmol/kg
PTHP: 0.8–8.5 pmol/L
PotassiumP: 3.5–5.3 mmol/L
Prolactin ♂P: <450 U/L
Prolactin ♀P: <600 U/L
PSAP: 0–4 mcg/mL
Protein (total)P: 60–80 g/L
Red cell folateB: 0.36–1.44 μmol/L
Renin (erect)P: 2.8–4.5 pmol/mL/h
Renin (recumbent)P: 1.1–2.7 pmol/mL/h
SodiumP: 135–145 mmol/L
TBGP: 7–17 mg/L
TSHP: 0.5–4.2 mU/L
T4P: 70–140 nmol/L
Free T4P: 9–22 pmol/L
TIBCS: 54–75 μmol/L
TriglyceridesP: 0.50–2.3 mmol/L
T3P: 1.2–3.0 nmol/L
Troponin TP: <0.1 mcg/L
Urate ♂P: 210–480 μmol/L
Urate ♀P: 150–390 μmol/L
UreaP: 2.5–6.7 mmol/L
Vitamin B12S: 0.13–0.68 nmol/L
Vitamin DS: 50 nmol/L
Arterial Blood Gases
pH7.35–7.45
PaCO₂4.7–6.0 kPa
PaO₂>10.6 kPa
Base excess±2 mmol/L
Urine
Cortisol (free)<280 nmol/24h
Hydroxyindole acetic acid16–73 μmol/24h
Hydroxymethylmandelic acid16–48 μmol/24h
Metanephrines0.03–0.69 μmol/mmol cr.
Osmolality350–1000 mosmol/kg
17-Oxogenic steroids ♂28–30 μmol/24h
17-Oxogenic steroids ♀21–66 μmol/24h
17-Oxosteroids ♂17–76 μmol/24h
17-Oxosteroids ♀14–59 μmol/24h
Phosphate (inorganic)15–50 mmol/24h
Potassium14–120 mmol/24h
Protein<150 mg/24h
Protein/creatinine ratio<3 mg/mmol
Sodium100–250 mmol/24h
Haematology
WCC4.0–11.0 ×10⁹/L
RBC ♂4.5–6.5 ×10¹²/L
RBC ♀3.9–5.6 ×10¹²/L
Hb ♂130–180 g/L
Hb ♀115–160 g/L
PCV ♂0.4–0.54 L/L
PCV ♀0.37–0.47 L/L
MCV76–96 fL
MCH27–32 pg
MCHC300–360 g/L
RDW11.6–14.6%
Neutrophils2.0–7.5 ×10⁹/L (40–75%)
Lymphocytes1.0–4.5 ×10⁹/L (20–45%)
Eosinophils0.04–0.44 ×10⁹/L (1–6%)
Basophils0–0.10 ×10⁹/L (0–1%)
Monocytes0.2–0.8 ×10⁹/L (2–10%)
Platelets150–400 ×10⁹/L
Reticulocytes0.8–2.0% / 25–100 ×10⁹/L
Prothrombin time10–14 s
APTT35–45 s
Paediatric
Pulse Rate (bpm)
Neonate140–160
Infant <1yr120–140
1–5 years110–130
5–12 years80–120
>12 years70–100
Respiratory Rate (tachypnoea)
0–2 months≥60/min
2–12 months≥50/min
1–5 years≥40/min
>5 years≥30/min
Blood Pressure (mmHg)
Term65/45
1 year75/50
4 years85/60
8 years95/65
10 years100/70
Weight Formulas
3–12 months(a + 9)/2 kg
1–6 years2a + 8 kg
>6 years(7a − 5)/2 kg
Haemoglobin (g/dL)
Term newborn13–20
1 month11–18
2 months10–15
1–2 years10–13
>2 years11–14
MUAC (6 months–5 years)
Obese>17.5 cm
Normal13.5–17.4 cm
At risk12.5–13.4 cm
Moderate malnutrition11.5–12.4 cm
Severe malnutrition<11.5 cm
Developmental Milestones
Social smile1.5 months
Head control4 months
Sits unsupported7 months
Crawls10 months
Stands unsupported10–12 months
Walks12–13 months
Talks18 months
CSF WBC (/mm³)
Term newborn0–25
>2 weeks0–5
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