Sexuality

Last updated: November 30, 2024

Overview

Definition of terms

TermDefinition
Sex (Sexual identity)A person’s biological sex, based on their chromosomes and external and internal features XY – biologic males (except for androgen insensitivity syndrome – develop as female in utero, doesn’t get menarche), XXY – biologic males (Klinefelter’s syndrome), XX – biologic female, X0 – biologic female (Turner’s syndrome).
Gender identityThe sex of a person’s psychlogical identity based on cultural sex roles.
Cis genderGender identity corresponds to biological sex
Trans genderGender identity does not correspond to biological sex
Sexual orientationDefined according to gender identity , not sex. Based on the sex towards which a person is sexually attracted to. Considered to be fluid, but generally a person assumes a label of identity
HeterosexualAttracted predominantly to the opposite gender
BisexualAttracted to both genders relatively equally
Homosexual (gay or lesbian)Attracted predominantly to the same gender
Transvestic FetishismSexual arousal from cross-dressing or playing the role of the opposite sex
Drag QueenCross-dressing for entertainment

Homosexuality

Homosexuality is a normal variant of sexual orientation (removed from the DSM). It is a label taken on by the patients, who will lead a normal life, but just happen to be attracted to the same gender. Most patients report attraction to the same sex since their early teen years. Their sexual development is however normal. Homosexuality is an IDENTITY, not a diagnosis. Therefore, for medical purposes, use MSM, WSW etc.

  • Why are there higher rates of MDD and suicide in homosexual patients?
    • Growing up in a culture that stigmatizes their sexuality. They don’t get much acceptance, may be abandoned etc.
  • What is NOT homosexuality?
    • Teenage or adolescent experimentation
    • Visual comparison of genitals
    • Handholding, kissing, etc. (especially among women or men in Arab countries. Take culture into consideration)

Masturbation

Masturbation is a normal, universal incidence. It’s the self-stimulation of genitals. Males tend to masturbate more than females (probably due to higher sex drive). Frequency peaks during adolescent years (experimentation/identity establishment). Not considered a disorder unless it interferes with activities of daily life.

  • Phallic stage
    • 1-2 year old infants engage in self-stimulation of genitals (exploration)
    • No sexual component
    • Normal

Paraphilias

Sexual arousal to objects, situations, and individuals, that is outside normative stimulation or what is considered to be acceptable (Take the patient’s culture into consideration). Must cause distress to the patient, affect the patient’s level of functioning or break the law in the jurisdiction to be considered a disorder.

Paraphilias

Involving non-human objectsDefinition
FetishismSexual arousal from objects associated with the human body. Garments, leather items, rubber and rubber items, and footwear
Transvestic fetishismSexual arousal from cross-dressing or playing the role of the opposite sex
Involving suffering/humiliation (SNM)
SadismSexual arousal from inflicting pain. Can be a big problem (sociopathic) if the other person does not consent to it, or if there is a high level of danger
MasochismSexual arousal from receiving pain. Disorder depends on the level of danger
Involving children
PedophiliaSexual arousal from intimate contact with OR watching of prepubescent children. Illegal in virtually every country
EphebophiliaSexual arousal from intimate contact with or watching of pubescent teens under the age of 18. Illegal. Not particularly a disorder from a biological standpoint.
Involving non-consenting persons
ExhibitionismSexual pleasure from exposure to unsuspecting strangers
FrotteurismSexual pleasure from rubbing up against an unsuspecting stranger
VoyeurismSexual pleasure from spying on sexual or private acts of unsuspecting strangers
  • Definition according to the AJP
    • Recurrent, intense, sexually arousing fantasies, sexual urges, or behaviours generally involving:
      • Non-human objects (Fetishism)
      • The suffering of humiliation of oneself or one’s partner (masochism, sadism)
      • Children (paedophilia, ephebophilia)
      • Non-consenting persons (exhibitionism, frotteurism, voyeurism)
  • Management

Gender Dysphoria

Trying to destigmatize (might be normal). A marked incongruence between one’s experienced/expressed gender and assigned gender, of at least 6 months duration. The individual has to be uncomfortable with their assigned sex (different from gender non-conformity). Adults may eventually get hormones/surgery to transition. Children can be given meds to halt puberty so that when they become adults they can make the decision. Sex change is irreversible.

  • Manifestation of gender dysphoria in children ***Remember to use common sense.
    • Preponderance to play with toys associated with other sex
    • Toilet habits associated with opposite sex
    • Friends primarily of opposite sex etc.
  • When to make a diagnosis of gender dysphoria
    • When the patient outwardly expresses disappointment with their current sex OR desire to be the opposite sex
    • Do not diagnose using behaviour alone (particularly in children)
  • Management
Sexual Response Cycle
Sexual Response Cycle

Disorders of Desire

May not be distressing to the patient. Psychotherapy may not be desired/necessary.

Disorders of desire

Disorder of desireDescription
Hypoactive sexual desireLow sexual desire (only a disorder if it is distressing to the patient)
Sexual aversion (disorder)Absent sexual interest (only a disorder if it is distressing to a patient). A lot of these patients have survived rape (are afraid of sex, which interferes with their ability to form relationships)

Disorders of Arousal

Female sexual arousal disorder

Failure to achieve adequate lubrication during sex. Often d/t anxiety, nervousness, fear etc.

  • Differentials
    • Medications that cause dryness (antihistamines, anticholinergics): Most commonly diphenhydramine for allergies and ipratropium for COPD (anything that dries out the mouth will dry the vagina)
  • Management
    • Alternative medications (if meds are the cause)
    • Psychotherapy
    • Synthetic lubricants

(Male) Impotence

Failure to achieve OR maintain erection. Seen commonly in older gents. The man may be psychologically aroused, but he may not be able to maintain an erection. R/o physiological causes.

  • How can distinguish between physiological causes of impotence a psychological causes (Psychogenic ED)
    • Ask the patient if he has an erection when he wakes up in the morning (nocturnal penile tumescence)
    • If yes, r/o physiological cause
  • Differentials
    • Diabetes Mellitus
    • Peripheral Vascular disease
    • Psychogenic ED (Seen in gents with anxiety disorders, repressed homosexuals etc.)
  • Treatment
    • Psychotherapy
    • Sildenafil, Tadalafil (can also be given as a placebo to psychogenic ED, as long as there are no contraindications -Pt on Nitrates etc.)

Disorders of Orgasm

Premature ejaculation syndrome

Ejaculation earlier than desired. Very very common. Commonly seen in teenage boys, young men, and college-age gents (”Soon as I put the tip in it’s over Doc…”)

  • Treatment
    • Squeeze technique” – wards off orgasm most of the time
    • SSRIs (Sertraline)

Anorgasmia

Recurrent or persistent inability to achieve orgasm

  • Differentials
    • SSRI use – Zoloft/Lexapro (switch to bupropion – Wellbutrin; Don’t use bupropion in pts with seizure disorders)
  • Treatment
    • Psychotherapy (difficult to treat if not related to meds
    • Switch to bupropion if on SSRI

Disorders of Pain During Sex

Dyspareunia

Pain associated with sex NOT associated with lack of lubrication or organic medical cause

  • Differentials
    • Female sexual arousal disorder (does not lubricate)
    • Endometriosis (pain comes from endometriomas)
    • Hypoplasia of vaginal introitus (vagina not big enough)
    • Lichen sclerosis (white plaques, treated with steroids)
    • Candidiasis (fungal infection, treated easily)
  • Treatment

Vaginismus

Involuntary contraction of the outer 1/3 of the vagina which results in pain during penetration

  • Treatment
    • Dilators (Gradually increase size) or Fingers

Reference Intervals
Biochemistry
ACTHP: <80 ng/L
ALTP: 5–35 U/L
AlbuminP: 35–50 g/L
AldosteroneP: 100–500 pmol/L
Alk. phosphataseP: 30–130 U/L
α-AmylaseP: 0–180 IU/dL
α-FetoproteinS: <10 kU/L
Angiotensin IIP: 5–35 pmol/L
ADHP: 0.9–4.6 pmol/L
ASTP: 5–35 U/L
BicarbonateP: 24–30 mmol/L
BilirubinP: 3–17 μmol/L
BNPP: <50 ng/L
CRPP: <10 mg/L
CalcitoninP: <0.1 mcg/L
Calcium (ionized)P: 1.0–1.25 mmol/L
Calcium (total)P: 2.12–2.60 mmol/L
ChlorideP: 95–105 mmol/L
CholesterolP: <5.0 mmol/L
VLDLP: 0.128–0.645 mmol/L
LDLP: <2.0 mmol/L
HDLP: 0.9–1.93 mmol/L
Cortisol AMP: 450–700 nmol/L
Cortisol MidnightP: 80–280 nmol/L
CK ♂P: 25–195 U/L
CK ♀P: 25–170 U/L
CreatinineP: 70–100 μmol/L
FerritinP: 12–200 mcg/L
FolateS: 2.1 mcg/L
FSHP: 2–8 U/L ♂; >25 menopause
GGT ♂P: 11–51 U/L
GGT ♀P: 7–33 U/L
Glucose (fasting)P: 3.5–5.5 mmol/L
Growth hormoneP: <20 mu/L
HbA1C (DCCT)B: 4–6%
HbA1C (IFCC)B: 20–42 mmol/mol
Iron ♂S: 14–31 μmol/L
Iron ♀S: 11–30 μmol/L
Lactate (venous)P: 0.6–2.4 mmol/L
Lactate (arterial)P: 0.6–1.8 mmol/L
LDHP: 70–250 U/L
LHP: 3–16 U/L
MagnesiumP: 0.75–1.05 mmol/L
OsmolalityP: 278–305 mosmol/kg
PTHP: 0.8–8.5 pmol/L
PotassiumP: 3.5–5.3 mmol/L
Prolactin ♂P: <450 U/L
Prolactin ♀P: <600 U/L
PSAP: 0–4 mcg/mL
Protein (total)P: 60–80 g/L
Red cell folateB: 0.36–1.44 μmol/L
Renin (erect)P: 2.8–4.5 pmol/mL/h
Renin (recumbent)P: 1.1–2.7 pmol/mL/h
SodiumP: 135–145 mmol/L
TBGP: 7–17 mg/L
TSHP: 0.5–4.2 mU/L
T4P: 70–140 nmol/L
Free T4P: 9–22 pmol/L
TIBCS: 54–75 μmol/L
TriglyceridesP: 0.50–2.3 mmol/L
T3P: 1.2–3.0 nmol/L
Troponin TP: <0.1 mcg/L
Urate ♂P: 210–480 μmol/L
Urate ♀P: 150–390 μmol/L
UreaP: 2.5–6.7 mmol/L
Vitamin B12S: 0.13–0.68 nmol/L
Vitamin DS: 50 nmol/L
Arterial Blood Gases
pH7.35–7.45
PaCO₂4.7–6.0 kPa
PaO₂>10.6 kPa
Base excess±2 mmol/L
Urine
Cortisol (free)<280 nmol/24h
Hydroxyindole acetic acid16–73 μmol/24h
Hydroxymethylmandelic acid16–48 μmol/24h
Metanephrines0.03–0.69 μmol/mmol cr.
Osmolality350–1000 mosmol/kg
17-Oxogenic steroids ♂28–30 μmol/24h
17-Oxogenic steroids ♀21–66 μmol/24h
17-Oxosteroids ♂17–76 μmol/24h
17-Oxosteroids ♀14–59 μmol/24h
Phosphate (inorganic)15–50 mmol/24h
Potassium14–120 mmol/24h
Protein<150 mg/24h
Protein/creatinine ratio<3 mg/mmol
Sodium100–250 mmol/24h
Haematology
WCC4.0–11.0 ×10⁹/L
RBC ♂4.5–6.5 ×10¹²/L
RBC ♀3.9–5.6 ×10¹²/L
Hb ♂130–180 g/L
Hb ♀115–160 g/L
PCV ♂0.4–0.54 L/L
PCV ♀0.37–0.47 L/L
MCV76–96 fL
MCH27–32 pg
MCHC300–360 g/L
RDW11.6–14.6%
Neutrophils2.0–7.5 ×10⁹/L (40–75%)
Lymphocytes1.0–4.5 ×10⁹/L (20–45%)
Eosinophils0.04–0.44 ×10⁹/L (1–6%)
Basophils0–0.10 ×10⁹/L (0–1%)
Monocytes0.2–0.8 ×10⁹/L (2–10%)
Platelets150–400 ×10⁹/L
Reticulocytes0.8–2.0% / 25–100 ×10⁹/L
Prothrombin time10–14 s
APTT35–45 s
Paediatric
Pulse Rate (bpm)
Neonate140–160
Infant <1yr120–140
1–5 years110–130
5–12 years80–120
>12 years70–100
Respiratory Rate (tachypnoea)
0–2 months≥60/min
2–12 months≥50/min
1–5 years≥40/min
>5 years≥30/min
Blood Pressure (mmHg)
Term65/45
1 year75/50
4 years85/60
8 years95/65
10 years100/70
Weight Formulas
3–12 months(a + 9)/2 kg
1–6 years2a + 8 kg
>6 years(7a − 5)/2 kg
Haemoglobin (g/dL)
Term newborn13–20
1 month11–18
2 months10–15
1–2 years10–13
>2 years11–14
MUAC (6 months–5 years)
Obese>17.5 cm
Normal13.5–17.4 cm
At risk12.5–13.4 cm
Moderate malnutrition11.5–12.4 cm
Severe malnutrition<11.5 cm
Developmental Milestones
Social smile1.5 months
Head control4 months
Sits unsupported7 months
Crawls10 months
Stands unsupported10–12 months
Walks12–13 months
Talks18 months
CSF WBC (/mm³)
Term newborn0–25
>2 weeks0–5
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