Updated on November 11, 2024 Overview Macrocytic anemia is characterized by Low Hb and High MCV (> 100). B12 and folate are required for the maturation of RBCs. Immature RBCs are larger, hence the increase in MCV in B12/Folate deficiency. A false normal MCV can occur in severely malnourished patients with both B12/Folate deficiency and...
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