Updated on November 8, 2024 Local Anaesthetics Local anesthetics provide analgesia and anaesthesia by disrupting the conduction of impulses along nerve fibers. They block voltage-gated Na+, thus inhibiting the influx of sodium and preventing an action potential from being reached. They are weak bases in equilibrium (pKa > 7.4). Anaesthetics with pKa closer to physiologic...
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