Haematology Comprehensive Quiz
Test your knowledge on Haematology by answering the questions provided in this quiz.
1.
Polycythemia vera is a disorder that results in:
2.
Which of the following is elevated in a polycythemia vera?
3.
A 55-year-old male with a history of myocardial infarction is scheduled for elective surgery. His hemoglobin is 8.2 g/dL. What is the most appropriate transfusion strategy?
4.
A 50-year-old man is undergoing an extensive surgical procedure with an estimated blood loss of 1500 mL. The surgeon anticipates further blood loss during the procedure. The patient has a history of cancer and the surgical site is not infected. What intraoperative blood management technique should be used to manage this patient’s blood loss effectively?
5.
Which of the following is a primary cause of non-cardiogenic pulmonary edema in transfusion reactions?
6.
Which of the following is not a component of dense granules of platelets?
7.
Which of the following is the gene involved in 95% of cases of polycythemia vera?
8.
Red blood cells are prepared from whole blood by removing the plasma. Shelf life of whole blood is:
9.
Which of the following viruses is the common cause of sickle cell aplastic crisis?
11.
Which of the following is the typical finding in the peripheral blood smear of a patient with multiple myeloma?
12.
What rare blood phenotype lacks A, B, and H antigens and has anti-A, anti-B, and anti-H antibodies?
13.
A 30 year old presents with abdominal distention and discomfort. on physical examination he is found to have massive splenomegaly extending into the iliac fossa. which of the following is the patient LEAST likely to be suffering from?
14.
A 55-year-old female undergoing liver transplant surgery has received 15 units of packed red blood cells over the past 24 hours. She now presents with hypocalcemia and muscle spasms. What is the most likely cause?
15.
Which of the following is the best initial step in the management of an Acute Hemolytic Transfusion Reaction?
17.
In urgent warfarin reversal for a patient requiring surgery, what combination is used when the INR is between 1.9 and 5?
18.
What is the standard definition of massive transfusion?
19.
Select the false statement regarding factors affecting rate of iron absorption:
20.
The administration of fresh frozen plasma in patients on Warfarin is MOST appropriate in which of the following scenarios?
21.
What is the most appropriate indication for cryoprecipitate transfusion?
22.
Which of the following hematologic disorders is characterized by the presence of the Philadelphia chromosome (t(9;22) translocation)?
23.
Which of the following best explains the occurrence of hypothermia during massive transfusion?
24.
Which of the following is NOT true about Hodgkin’s lymphoma?
25.
Starry sky appearance is seen in:
26.
Which of the following is not a vitamin K dependent factor:
27.
Which of the following is the storage temperature for Packed Red Blood Cells (pRBCs)?
28.
Which one of the following will not result in microcytic hypochromic anemia?
29.
Which of the following regarding hemostasis is false?
31.
The most common subtype of Non-Hodgkin lymphoma in African children is?
32.
Which of the following increases the shelf life of RBCs by serving as a precursor to ATP synthesis?
33.
A 70-year-old patient presents with severe anemia (Hb 6 g/dL) and a history of IgA deficiency with anaphylaxis. What blood product should be administered?
34.
A 37 yo male presents with severe fatigue, frequent nose bleeds, and gingival masses. The abnormal cells seen in the blood smear show tissue paper nuclei. What is the diagnosis?
35.
Which infectious agent is NOT typically screened for in donated blood?
36.
CD20 is a phosphoprotein generally expressed in?
37.
Which of the following is true about polycythemia vera?
38.
Which of the following coagulation factors is not involved in the intrinsic pathway?
39.
PML-RARA fusion gene is associated with:
40.
Which of the following is a common complication of massive transfusion due to citrate toxicity?
41.
Massive blood transfusion may lead to:
42.
Which of the following is not true regarding the Reed-Sternberg cell?
43.
Which of the following is an established risk factor for Acute Myeloid Leukemia?
44.
Which transfusion reaction is most commonly associated with IgA deficiency?
45.
Which of the following conditions is characterized by a deficiency of the enzyme glucose-6-phosphate dehydrogenase (G6PD)?
46.
Which of the following is CD15 and CD30 negative variant Hodgkin Lymphoma?
47.
Which of the following is the most common inherited bleeding disorder?
48.
A 45-year-old male with a history of IgA deficiency is undergoing surgery and requires a transfusion. Within minutes of starting the transfusion, he develops respiratory distress, hypotension, and a rash. What is the most likely diagnosis and appropriate initial management?
49.
Which of the following interventions is most appropriate for managing a patient with transfusion-related acute lung injury (TRALI)?
50.
Which antibody is commonly elevated in Waldenstrom macroglobulinemia?
51.
Deficiency of factor XI leads to the following condition:
52.
Molecular abnormalities associated with polycythemia vera:
53.
Which component in CPDA prevents clot formation by binding to calcium?
54.
A 35-year-old woman with Von Willebrand Disease is experiencing heavy menstrual bleeding. Her fibrinogen level is 80 mg/dL. What is the most appropriate transfusion therapy?
55.
A microscopic picture is shown below. What is the diagnosis?
56.
What is the primary mechanism behind delayed hemolytic transfusion reaction?
57.
A 30-year-old male undergoes exploratory laparotomy. He receives 4 RBC, 2 FFP and 2 hours after the surgery he becomes hypoxemic and hypotensive. A CXR shows bilateral pulmonary edema and PCWP is 8 mmHg (normal is 6 - 12). Which of the following is the most appropriate management of this patient?
58.
A 32-year-old female with a history of multiple transfusions presents 7 days after receiving a transfusion with jaundice and low hemoglobin levels. What is the most likely diagnosis?
59.
Starry sky appearance is seen in:
60.
What is the primary reason lactated Ringer’s solution is not compatible with pRBC transfusion?
61.
A 25-year-old male with no previous transfusions presents with fever, chills, and hypotension shortly after receiving a blood transfusion. What is the most likely cause?
62.
Which of the following cells is diagnostic for Hodgkin Lymphoma:
63.
Which of the following is correct about the presentation of polycythemia vera?
64.
Warfarin mediates anticoagulation by:
65.
A patient with a recent organ transplant develops signs of graft-versus-host disease after a blood transfusion. Which blood product modification could have prevented this?
66.
Which of the following is a non-fibrin specific fibrinolytic agent?
67.
A 60-year-old male with a history of heart failure is receiving a blood transfusion. A few hours after the transfusion, he develops dyspnea, elevated jugular venous pressure, and crackles on lung auscultation. What is the most likely diagnosis and appropriate intervention?
68.
Which one of the following statements is false?
70.
A 35-year-old female presents with petechiae and purpura 10 days after receiving a blood transfusion. She has a history of multiple transfusions and a recent pregnancy. What is the most likely diagnosis, and what is the treatment?
71.
Which of the following is the primary cause of iron deficiency anemia in adults?
72.
Which anticoagulant in RBC storage is associated with a 42-day shelf life?
73.
The specimen for coagulation testing is?
74.
A clinical feature commonly seen in Von Willebrand disease is?
75.
Which of the following is an indicator of good prognosis for pre-B childhood ALL?
76.
Which of the following conditions is NOT a common indication for massive transfusion?
77.
On what chromosome is the sickle cell gene point mutation?
79.
Which one of the following stains may be used to characterise bone marrow fibrosis?
80.
A 60-year-old patient undergoing cardiac surgery has an INR of 2.8 and begins to bleed excessively. What is the most appropriate initial treatment?
81.
Which of the following is a long term complication of therapy with cytotoxic drugs:
82.
Causes of the anticoagulant effect of a massive blood transfusion includes:
83.
Deficiency of which of the following causes hereditary spherocytosis?
84.
Romanowsky stains are used universally for routine staining of blood films. Which of the following is not among them?
85.
Pappenheimer bodies are composed of?
86.
A 70-year-old male patient presents with bone pain in the back and renal failure. Bone marrow aspirate shows abnormal blasts. Which finding is expected in the RBCs of the peripheral smear?
87.
Ineffective erythropoiesis is characteristic of which one:
88.
Which of the following is a poor prognostic indicator in acute lymphoblastic leukemia (ALL):
89.
Erythrocyte sedimentation rate is markedly elevated in the following except:
