Classification of Wounds

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Tidy vs Untidy wound

Type of woundCharacteristicExamplesHealing
Tidy woundIncised, Clean, no tissue lossSurgical incision, Stab, CutsPrimary intention
Untidy woundsIrregular, tissue loss, devitalized tissue, contaminatedCrush, Avulsion/Degloving, BurnSecondary intention

Open wounds

The skin has been breached and underlying tissue is exposed

WoundDescription
Clean incisionTidy, simple, clean cut wound with linear edges
CutWound with uneven edges due to a combination of sharp and blunt forces
AbrasionShallow, irregular wound involving superficial skin layers that results from skin contact with a rough surface or any surface at high speed
LacerationDeeper, tear-like wound, often with irregular edges, typically caused by sharp trauma or focused blunt trauma
AvulsionTissue is forcibly detached from its normal attachment or insertion
PunctureSmall rounded wound that results from thin, pointed objects
Penetrating woundWound caused by any object that breaks through the skin to underlying tissue or organs

Closed wounds

The skin is intact, but the underlying tissue has been damaged

WoundDescription
ContusionWound caused by direct blunt trauma that causes damage to small vessels and capillaries producing bruising (skin discolouration) in subcutaneous tissue
HematomaWound caused by trauma that damages small vessels and capillaries allowing blood to collect in a potential space

Mechanism of injury

MechanismExamples
Mechanical woundAbrasion, puncture, incision, cut, crush, tear, bite wound, gunshot wound
Chemical woundDue to acids and alkali
Radiation woundDue to radiation exposure
Thermal destructionBurn or frostbite

Primary, Secondary, and Tertiary intention

Types of wound healing

Type of healingDescriptionExample of wound
First intentionWound edges are approximated by suturing, staples, or adhesiveSurgical wound, clean incision
Secondary intentionThe wound heals slowly by granulation tissue and scar formation and closes by re-epithelializationTraumatic wound, highly contaminated wound, extensive soft tissue loss
Tertiary intention (Delayed primary closure)The wound is treated by repeated debridement and finally approximatedTraumatic wound with high infection risk

Healing by primary vs secondary intention

Primary intentionSecondary intention
Tissue deficitSmallerLarger
Mechanism of healingEpithelial regenerationGranulation tissue. Pale, avascular scar formation
Myofibroblast contractionMinimalMarked
Fibrin clotSmallerLarger
InflammationLess intenseMore intense
Secondary inflammation mediated damageLess potentialMore potential
Granulation tissueSmall amountsLarger amounts
Scar tissueSmaller massGreater mass
ExudateLess exudateMore exudate
Necrotic debrisLessMore

Ulcer

An ulcer is a chronic wound that is defined as a break in the continuity of the covering epithelium in either skin or mucous membranes due to molecular death. The most common ulcers are venous, arterial, or mixed ulcers. These three account for 70% of all ulcers while 50% are caused by venous stasis alone.

A chronic non-healing ulcer

Location of ulcers based on etiology

UlcerDescriptionCommon Location
Neuropathic and Traumatic ulcersDue to loss of sensation → inability to withdraw from painful stimulus or trauma → repeated trauma → ulcerationPressure bearing regions
Venous (Varicose) ulcersDue to hypoxia. Painful, easily recur and persist for many years.Medial and lateral malleoli
Arterial ulcerDue to ischemia caused by atherosclerosis or peripheral arteries. Appear punched out and well demarcated with round shape and pale, non-granulating, often necrotic baseDorsum of the toes, dorsum of the foot, and in-between toes
Diabetic ulcerA mixed ulcer due to ischemia + neuropathic changes + systemic metabolic dysfunction + immune dysfunction causing ulceration and impaired healingNo particular site since any ulcer with imaired healing (neuropathic/arterial/traumatic/varicose) due to diabetes is termed a diabetic ulcer. However bullae tend to appear in the nape and back.
Decubitus (Pressure) ulcersMechanical pressure compresses arterioles and venules causing ischemia and hypoxiaBack of head, shoulder, elbow, hip, sacrum, ischial tuberosity, greater trochanter, medial and lateral condyles, malleoli, and heels
  • Features suggestive of malignancy in ulcers
    • Margins: Irregular with nodules
    • Egde: Everted edges
    • Floor: red and bleeds easily on palpation
    • Surrounding skin: inflammed and indurated (hard)
  • Investigations for patients with chronic ulcers
    • CBC: look for anemia
    • ESR: monitor for infection
    • RBS and HbA1C: for glycemic control
    • U/E/Cs: for uremia
    • VDRL: for syphillis
    • HIV: for HIV
    • Chest X-ray: for TB
    • EKG: to rule out IHD if atherosclerosis is suspected
    • Local smear for culture
    • X-ray of the affected part
    • 4 quadrant edge biopsy
  • Stigmata of Tuberculosis to look out for in a patient with an ulcer
    • Phlyctenular conjunctivitis
    • Matted Lymphadenopathy
    • Scars and Sinuses in the neck
  • Stigmata of Leprosy to look out for in a patient with an ulcer
    • Hypopigmented, anesthetic patches
    • Thickened ulnar posterio tibial, and great auricular nerves
    • Trophic ulcers (pressure ulcer)
    • Deformed phalanges
    • Leonine facies (due to collapse of the nasal bridge and lateral 1/3 of eyebrows)

Diabetic ulcer

  • 4 ways in which diabetes impairs healing of ulcers
    1. Hyperglycemia promotes the proliferation of bacteria and glycosylates collagen making it brittle
    2. Decreases blood supply to the ulcer due to small and large vessel disease
    3. Ulcer is prone to repeated, unnoticed trauma as a result of neuropathy
    4. Deficient fibroblast reaction

Wagner Grading of diabetic foot ulcers

Depth-ischemia classification of diabetic foot ulcer
Depth-ischemia classification of diabetic foot ulcer
GradeDescription
Grade 0Intact skin
Grade ISuperficial ulcer
Grade IIDeep ulcer
Grade IIIUlcer with abscess or bone involvement or osteomyelitis
Grade IVForefoot gangrene (localized)
Grade VFull foot gangrene (extensive)

Decubitus (Pressure) ulcers

Decubitus ulcer on the heal of a foot

Staging of decubitus ulcers

StageDescription
Stage IIntact skin. Change in color, consistency, or temperature
Stage IIPartial-thickness loss of skin involving the epidermis and dermis
Stage IIIFull-thickness skin loss including subcutaneous tissue but not fascia
Stage IVDamage to muscle, bone, and other supporting tissue, may have undermining of tissue
  • Risk factors for development of pressure ulcers
    • Sensory deficits
    • Moisture
    • Immobility
    • Inactivity
    • Malnutrition
    • Friction and shear
  • Prevention of pressure ulcers
    • Reduce external pressure
      • Reposition every 2 hours
      • Pillows or thick padding areas at risk
    • Keep the skin clean and dry
    • Adequate pain relief to allow for activity and mobility
    • Manage systemic conditions that place the patient at risk of developing pressure ulcers
Areas at risk of pressure sores
Areas at risk of pressure sores

Gunshot Wound (GSW)

The higher the projectile velocity of a missile, the greater the damage. Low velocity missiles from pistols drill only narrow tracks with little damage around them. in addition to causing extensive cavitation, high velocity missiles form a partial vacuum in their path that sucks in debris. Missile wounds may take curious paths. They may be deflected by bone, or be influenced by the position of the patient at the time of injury. A multi-disciplinary care team is required for GSW. GSW should not be closed primarily. Delayed primary closure after initial debridement, or healing by secondary intention is preferred. Bullets and fragments are removed only where indicated. Gunshot wounds are discussed more in depth in the forensic medicine cheat sheets.

Types of injury

Type of injuryWeaponProjectile velocity
Low velocityHandgun, some rifles< 350 m/s (1200 fps)
Medium velocityShotgun: potential for massive soft tissue destruction. The wad may stay in the wound and form a nidus of infection350 – 650 m/s (1200 – 2100 fps)
High velocityMilitary or Hunting rifles> 600 m/s (>2000 fps)
  • Complications of GSW
    • Compartment syndrome: common after high velocity wounds. More common with proximal fractures of the forearm
    • Vascular injury: findings include pulsatile bleeding, absent pulse, bruit, thrill. ABI and angiography can be performed if there is concern.
    • Spinal injury: GSW is the 3rd most common cause of spinal injury. Cervical spine GSW can be associated with airway compromise (84%)
    • Infection: GSW tracts are non-sterile. 24 hours IV antibiotics (1st gen cephalosporins) for low-velocity injuries (Gustillo I/II) and 72 hours IV antibiotics (1st gen cephalosporin + gentamicin) for high-velocity injuries (Gustillo III)
    • Fractures: Low velocity injuries can be treated as Gustilo I/II while high velocity injuries can be treated as Gustilo III. GSW has increased comminution and greater soft-tissue stripping and bone loss.
    • Retained projectiles and fragments: retained fragments can be left in situ. Indications for removal include: intra-articular, intra-vascular, subcutaneous, lead toxicity, peri-spinal and peri-neural
  • Compartment syndrome
    • Common after high velocity wounds due to soft-tissue trauma/bleeding/oedema
    • More common with proximal fractures of the forearm
  • Vascular injury and hemorrhage
    • Findings include pulsatile bleeding, absent pulse, bruit, thrill
    • Damage control surgery e.g. shunting can be performed
    • ABI and Angiography can be performed if there is concern
  • Peripheral nerve injury
    • Majority of nerve dysfunction is neuropraxia, particularly in low velocity wounds
  • Life-saving interventions in GSW
    • Hemorrhage control and resuscitation
    • Chest tubes (even bilateral chest tubes)
    • Laparotomy

Classification Surgical Wounds

Colonized body cavities = respiratory, alimentary,, genital, or urinary tracts

WoundDescriptionExampleInfective rateNeed for prophylaxis
Clean woundElective wound. Primarily closed withour drain. No opening of colonized body cavities. No break in sterile technique.Hernioplasty, Excisions, Thyroidectomy, Brain surgery, Joint surgery, arterial and venous surgery, heart surgery1-5%No
Clean contaminated woundElective wound. Controlled opening of normally colonized body cavities. Minimal spillage. No break in the sterile technique.Appendicectomy, Gastrojejunostomy, Pancreaticobiliary surgeries, Lung resection, Cholecystectomy, Gastrectomy, Prostatectomy3-11%Prophylaxis may be required
Contaminated woundAcute, non-purulent inflammation. Break in sterile technique or spillage from hollow organs. Open, fresh accidental wound.Penetrating trauma < 4h from injury, Chronic open wound, acute abdomen, removal of acute appendicitis, open cardiac massage during a case10-17%Prophylactic antibiotics required – 1 hour prior to incision, 2nd and 3rd dose q8h
Dirty woundPurulent abscess. Traumatic wound from a dirty source with retained, devitalized tissue. Surgical wound involving existing infection or free perforation.Penetrating trauma > 4 hours from injury, abscess, perforated viscus with peritonitis, fecal peritonitis27-40%Treatment required instead of prophylaxis
Jeffrey Kalei
Jeffrey Kalei
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