Overview Shock is defined as a state of global cellular and tissue hypoxia due to either reduced oxygen delivery, increased oxygen consumption, inadequate oxygen utilization, or a combination of these…...
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Overview NMBAs facilitate intubation, mechanical ventilation, and surgical relaxation. Categories of NMBAs Category Examples Depolarizing Succinylcholine Non-depolarizing Atracurium, Cisatracurium, Rocuronium, Vecuronium Agent ED 95 (mg/kg) Intubating Dose (mg/kg) Onset (min…...
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Local Anaesthetics Local anesthetics provide analgesia and anaesthesia by disrupting the conduction of impulses along nerve fibers. They block voltage-gated Na+, thus inhibiting the influx of sodium and preventing an…...
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Overview IV induction agents target GABA receptors (most common), NMDA receptors, and alpha-2 receptors to cause anaesthesia. Propofol and Barbiturates decrease the rate of dissociation of GABA from its receptors…...
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Overview Historically there have been several accounts of the use of various forms of anesthesia from cannabis and other herbs to carotid compression. The earliest account of modern anesthesia was…...
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Overview Sickle cell disease is caused by a point mutation in the beta-globin gene found in chromosome 11. It results in a substitution of glutamine to valine at position 6,…...
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Overview Meningitis is a life-threatening infection of the meninges. Acute bacterial meningitis: rapid onset of Sx, identified by routine laboratory techniques Chronic meningitis: ongoing Sx of meningitis for ≥ 4…...
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Overview Malaria is an infectious disease caused by Plasmodium spp. It is one of the leading causes of morbidity and mortality, particularly in children < 5yo in Kenya. Plasmodium falciparum…...
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Overview Sudden infant death syndrome (SIDS) is the sudden unexplained death of a child under the age of 1 year. It occurs while sleeping or while the child is assumed…...
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Pneumonia is still the leading killer of children worldwide (29% of pediatric deaths worldwide, 158 million cases per year; 3 million deaths per year). The death rates in underdeveloped countries…...
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